Anti-Calcipressin 2抗體,鈣調(diào)神經(jīng)磷酸酶調(diào)節(jié)蛋白2抗體說明書產(chǎn)品經(jīng)無數(shù)次市場驗證，若出現(xiàn)質(zhì)量問題可無條件換貨或退貨,詳細信息：
產(chǎn)品詢價 或（成）客服
英文名稱 Calcipressin 2
抗體名稱 Anti-Calcipressin 2抗體,鈣調(diào)神經(jīng)磷酸酶調(diào)節(jié)蛋白2抗體說明書
別 名 DSCR1L1; Calcipressin 2; Calcipressin-2; CSP2; Down syndrome candidate region 1-like 1; Down syndrome critical region gene 1 like 1 protein; MCIP2; Myocyte enriched calcineurin interacting protein 2; Myocyte-enriched calcineurin-interacting protein 2; RCAN2; RCAN2_HUMAN; RCN2; Regulator of calcineurin 2; Thyroid hormone responsive protein ZAKI4; Thyroid hormone-responsive protein ZAKI-4; ZAKI4.
研究領域 心血管 細胞生物 染色質(zhì)和核信號 神經(jīng)生物學 信號轉(zhuǎn)導 細胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
產(chǎn)品應用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
性 狀 Lyophilized or Liquid
濃 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Calcipressin 2
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
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抗體原理
（1）特異性結(jié)合抗原：抗體本身不能直接溶解或殺傷帶有特異抗原的靶細胞，通常需要補體或吞噬細胞等共同發(fā)揮效應以清除病原微生物或?qū)е虏±頁p傷。然而，抗體可通過與病毒或毒素的特異性結(jié)合，直接發(fā)揮中和病毒的作用。
（2）激活補體：IgM、IgG1、IgG2和IgG3可通過經(jīng)典途徑激活補體，凝聚的IgA、IgG4和IgE可通過替代途徑激活補體。
（3）結(jié)合細胞：不同類別的免疫球蛋白，可結(jié)合不同種的細胞，參與免疫應答。
（4）可通過胎盤及粘膜：免疫球蛋白G（IgG）能通過胎盤進入胎兒血流中，使胎兒形成自然被動免疫。免疫球蛋白A（IgA）可通過消化道及呼吸道粘膜，是粘膜局部抗感染免疫的主要因素。
（5）具有抗原性：抗體分子是一種蛋白質(zhì)，也具有刺激機體產(chǎn)生免疫應答的性能。不同的免疫球蛋白分子，各具有不同的抗原性。
（6）抗體對理化因子的抵抗力與一般球蛋白相同：不耐熱，60～70℃即被破壞。各種酶及能使蛋白質(zhì)凝固變性的物質(zhì)，均能破壞抗體的作用?？贵w可被中性鹽類沉淀。在生產(chǎn)上?？捎昧蛩徜@或硫酸鈉從免疫血清中沉淀出含有抗體的球蛋白，再經(jīng)透析法將其純化。
產(chǎn)品介紹 Calcineurin is a Ca(2+) dependent protein phosphatase that is involed in several neuornal functions. Proteins belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFATs (Nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. Calcipressin-2, also known as RCAN2 and DSCR1L1 (Down syndrome candidate region 1-like 1), is a 197 amino acid protein that is highly expressed in both the cytoplasm and nucleus of neurons and is the only RCAN family member that is found in glial cells. Calcipressin-3, also known as RCAN3 and DSCR1L2 (Down syndrome candidate region 1-like protein 2), is a 241 amino acid protein that potentially is involved in central nervous system development. Calcipressin-3 interacts with cardiac troponin I, suggesting that it may play a role in cardiac contraction events.
運輸方面：現(xiàn)貨供應，一般為快遞運輸，江浙滬隔天到，外地及偏遠地方三至五天時間到貨。
