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K0013紡錘菌素二鹽酸/Netropsin dihydrochloride
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產(chǎn)品介紹
Description
Biochem/physiol Actions Unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.
Caution Protect from light.
Properties
biological source from Streptomyces netropsis
assay ≥98% （HPLC and TLC）
form powder
color faint yellow
solubility H2O: 1 mg/mL
storage temp. −20°C
Safety
Personal Protective Equipment dust mask type N95 （US）, Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
RIDADR UN2811 6.1/PG 3
WGK Germany 3
RTECS DW2973000
References
reference Zimmer, C., et al., Protection of （dA.dT） cluster regions in the DNAase I cleavage of DNA by specific interaction with netropsin. Nucleic Acids Res. 8, 2999-3010, （1980） Abstract
Beerman, T.A., et al., Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim. Biophys. Acta 1090, 52-60, （1991） Abstract
Poot, M., et al., Distinct patterns of cell cycle disturbance elicited by compounds interfering with DNA topoisomerase I and II activity. Exp. Cell Res. 218, 326-330, （1995） Abstract
Poot, M., et al., The minor-groove binding DNA-ligands netropsin, distamycin A and berenil cause polyploidisation via impairment of the G2 phase of the cell cycle. Cell Struct. Funct. 15, 151-157, （1990） Abstract
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