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上海研盟生物科技有限公司Anti-Fibulin 1抗體*,主要應(yīng)用于WB、IHC、IF、ELISA、流式細(xì)胞術(shù)等實(shí)驗(yàn)中。說明書隨貨發(fā)送,您也可以直接我司在線客服索取??头?/span>
英文名稱:Anti-Fibulin 1 antibody
中文名稱:“衰老關(guān)鍵蛋白”抗體
“衰老關(guān)鍵蛋白”抗體保存條件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
“衰老關(guān)鍵蛋白”抗體,Anti-Fibulin 1抗體功能區(qū)的作用:
(1)VL和VH:結(jié)合抗原決定簇(FV區(qū))
(2)CL和CH:具有同種異型的遺傳標(biāo)記
(3)CH2:結(jié)合補(bǔ)體
(4)CH3:結(jié)合Fc受體
抗原結(jié)合點(diǎn)由L鏈和H鏈超變區(qū)組成,與相應(yīng)抗原上的表位互補(bǔ),借助靜電力,氫鍵以及范德華力等次級(jí)鍵相結(jié)合。
★研盟生物★“衰老關(guān)鍵蛋白”抗體,Anti-Fibulin 1抗體
免疫組化結(jié)果的判斷:
對(duì)免疫組化結(jié)果的判斷應(yīng)持科學(xué)的慎重態(tài)度,要準(zhǔn)確判斷陽性和陰性,排除假陽性和假陰性結(jié)果,必須嚴(yán)格對(duì)照實(shí)驗(yàn),對(duì)新發(fā)現(xiàn)的陽性結(jié)果,除有對(duì)照實(shí)驗(yàn)結(jié)果之外,應(yīng)進(jìn)行多次重復(fù)實(shí)驗(yàn),可用幾種方法進(jìn)行驗(yàn)證。必須學(xué)會(huì)判斷特異性染色和非特異性染色,對(duì)初學(xué)者更為重要,否則會(huì)得出不科學(xué)的結(jié)論。特異性染色和非特異性染色的鑒別點(diǎn)主要在于特異性反應(yīng)產(chǎn)物常分布于特定的部位。如胞漿內(nèi),也有分布在細(xì)胞核和細(xì)胞表面的,即具有結(jié)構(gòu)性。特異性染色表現(xiàn)為在同一切片上呈現(xiàn)不同程度的陽性染色結(jié)果。非特異性染色表現(xiàn)為無一定的分布規(guī)律,常呈某一部位成片的均勻著色,細(xì)胞和周圍的結(jié)締組織均無區(qū)別的著色,或結(jié)締組織呈現(xiàn)很強(qiáng)的染色。非特異性染色常出現(xiàn)在干燥切片的邊緣,有刀痕或者折疊的部位。在過大的組織塊,中心固定不良也會(huì)導(dǎo)致非特異性染色。有時(shí)可見非特異性染色和特異性染色同時(shí)存在,由于過強(qiáng)的非特異性染色背景不但影響對(duì)特異性染色結(jié)果的觀察和記錄,而且令人對(duì)其特異性結(jié)果產(chǎn)生懷疑。
免疫組化的呈色深淺可反映抗原存在的數(shù)量,可作為定性、定位和定量的依據(jù)。
1.陽性細(xì)胞染色分布有三種類型:細(xì)胞漿、細(xì)胞核、細(xì)胞膜表面。大部分抗原見于細(xì)胞漿,可見于整個(gè)胞漿或部分胞漿
2.陽性細(xì)胞分布可分為灶型和彌漫性
3.由于細(xì)胞內(nèi)含抗原量不同,所以染色強(qiáng)度不一。如果細(xì)胞之間染色強(qiáng)度相同,常提示其反應(yīng)為非特異性
4.陽性細(xì)胞染色定位于單個(gè)細(xì)胞,且與陰性細(xì)胞相互交雜分布;而非特異性染色常不限于單個(gè)細(xì)胞,而是累及一片細(xì)胞。
5.切片邊緣、刀痕或褶皺區(qū)域,壞死或擠壓的細(xì)胞區(qū),膠原結(jié)締組織等,常表現(xiàn)為相同的陽性染色強(qiáng)度,不能用于判斷陽性。
“衰老關(guān)鍵蛋白”抗體,Anti-Fibulin 1抗體簡(jiǎn)單介紹:
產(chǎn)品別名:Basement membrane protein 90; BM 90; FBLN; FBLN1; FIBL 1; FIBL1; Fibulin 1; FBLN1_HUMAN; FIBL-1; Fibulin-1.
抗體來源:Rabbit or Mouse
保質(zhì)期:1年
克隆類型:Polyclonal or monoclonal
性 狀:Lyophilized or Liquid
濃 度:1mg/1ml
背景介紹:Fibulin-1 is an extracellular matrix protein often associated with fibronectin (FN) in vivo. Fibulin-1 was found to have pronounced inhibitory effects on the cell attachment and spreading promoted by FN. Fibulin-1 was also found to inhibit the motility of a variety of cell types on FN substrata. For example, the FN-dependent haptotactic motility of breast carcinoma (MDA MB231) cells, epidermal carcinoma (A431), melanoma (A375 SM), rat pulmonary aortic smooth muscle cells (PAC1) and Chinese hamster ovary (CHO) cells was inhibited by the presence of fibulin-1 bound to FN-coated Boyden chamber membranes. Cells transfected to overproduce fibulin-1 displayed reduced velocity, distance of movement and persistence time on FN substrata. Similarly, the incorporation of fibulin-1 into FN-containing type I collagen gels inhibited the invasion of endocardial cushion mesenchymal cells migrating from cultured embryonic heart explants. By contrast, incorporation of fibulin-1 into collagen gels lacking FN had no effect on the migration of endocardial cushion cells.
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