Rabbit Anti-TRF3
FROM:ABCAM
Catalog Number:RS-20521R
Quantity size:0.1ml （dilute with pH 7.4 0.01 M PBS or diluent of antibody）
Background: TRF3 is a ubiquitously expressed protein that is implicated in the control of omere length. TRF3, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localised to all human omeres in metaphase chromosomes. TRF3 is thought to protect chromosome ends by maintaining the correct structure at omere termini. The use of mutant forms of TRF3 has implicated a role for TRF3 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF3 resulted in apoptosis in a subset of mammalian cell types. TRF3 is overexpressed in a number of human tumors and overexpression of TRF3 has been shown to be oncogenic in a mouse model of carcinogenesis.
Specificity : ·anti-TRF3 is a rabbit monoclonal antibody unconjugated
·specific for TRF3 of human, mouse, rat
·use for western blot, elisa, immunoprecipitation
and immunohistochemistry
·affinity chromatography purification, purity :>95%
·isotype: IgG
·mol wt: 91kDa
Rabbit Anti-TRF3
Application : · Immunohistochemistry: 1:100-500
· ELISA: 1:500-1000
· Western blotting 1:100-500
· Optimal working dilutions must be determined by the end user.
Storage: Store at –20 ºC for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20ºC. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ºC.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Rabbit Anti-TRF3
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