biomomentum Mach-1微觀力學(xué)測(cè)試系統(tǒng),Mach-1 is a micromechanical testing system，拉伸壓力扭力彈性壓力剪切應(yīng)變測(cè)試
多載荷多物理場(chǎng)耦合微觀力學(xué)性能原位測(cè)試系統(tǒng)
之多功能多軸向測(cè)試分析
Mach-1微觀力學(xué)測(cè)試系統(tǒng)，由加拿大BIOMOMENTUM公司研發(fā)，于2000年開始在科研機(jī)構(gòu)應(yīng)用，不斷研發(fā)，目前已經(jīng)形成了五種不同的測(cè)試子型號(hào)，產(chǎn)品得到了業(yè)界廣泛的認(rèn)可和推廣。該系統(tǒng)初該系統(tǒng)為軟骨力學(xué)性能檢測(cè)所研發(fā)，此后集成了多種配置以滿足更多生物組織和軟質(zhì)材料力學(xué)性能的測(cè)量和評(píng)估。Mach-1儀器性能特點(diǎn)--模塊化設(shè)計(jì)，簡(jiǎn)易操作平臺(tái)，面向用戶設(shè)計(jì)，廣泛應(yīng)用于生物材料檢測(cè)，高分子材料檢測(cè)以及數(shù)字教學(xué)等領(lǐng)域。
該系統(tǒng)模塊化集成壓縮、張力、剪切、摩擦、彎曲（三點(diǎn)彎曲和四點(diǎn)彎曲均可）、撓曲、穿刺、扭轉(zhuǎn)和2D/3D壓痕、3D輪廓及多力混合耦連測(cè)試的一體化微觀力學(xué)測(cè)試裝置。能對(duì)生物組織、聚合物、凝膠、生物材料、膠囊、粘合劑和食品進(jìn)行精密可靠的機(jī)械刺激和表征。允許表征的機(jī)械性能包括剛度、強(qiáng)度、模量、粘彈性、塑性、硬度、附著力、腫脹和松弛位移控制運(yùn)動(dòng)。
相比于傳統(tǒng)的大型力學(xué)測(cè)試系統(tǒng)，Mach-1微觀力學(xué)測(cè)試系統(tǒng)總體較小，可以實(shí)現(xiàn)桌面化的操作流程，操作過(guò)程簡(jiǎn)便。Mach-1測(cè)試方法面，是多樣化的材料力學(xué)表征工具，是科學(xué)家、工程師和其他各領(lǐng)域用戶的佳選擇。在動(dòng)態(tài)力學(xué)分析、薄膜、復(fù)合物、聚合物、生物產(chǎn)品、醫(yī)學(xué)鑒定和水凝膠等領(lǐng)域都有廣泛應(yīng)用。
材料力學(xué)性能簡(jiǎn)介：
材料力學(xué)性能是指材料在不同環(huán)境(溫度、介質(zhì)、濕度)下，承受各種外加載荷(拉伸、壓縮、彎曲、扭轉(zhuǎn)、沖擊、交變應(yīng)力等)時(shí)所表現(xiàn)出的力學(xué)特征。
測(cè)試意義及適用范圍：
材料力學(xué)性能可以應(yīng)用到生產(chǎn)的任何階段，從測(cè)試原材料質(zhì)量直到檢查制成品的耐用性。 測(cè)試可對(duì)廣泛多樣的生物樣品、材料和產(chǎn)品進(jìn)行，包括軟組織、軟骨組織、皮膚組織、凝膠組織、高分子材料、生物產(chǎn)品、醫(yī)學(xué)鑒定和水凝膠等。力學(xué)性能測(cè)試可幫助企業(yè)向客戶證明其產(chǎn)品的力學(xué)性能、穩(wěn)定性和安性，從而獲得基礎(chǔ)數(shù)據(jù)和競(jìng)爭(zhēng)勢(shì)。
系統(tǒng)亮點(diǎn)：
體積小方便攜帶，移動(dòng)后易于重新定位;
可在標(biāo)準(zhǔn)的培養(yǎng)皿中進(jìn)行力學(xué)刺激實(shí)驗(yàn);
用戶友好的數(shù)據(jù)采集和分析軟件;
可滿足作為里想的實(shí)驗(yàn)和教學(xué)工具;
可j確測(cè)試微米至厘米范圍內(nèi)低力學(xué)性質(zhì)的樣品;
大范圍高精度多軸測(cè)試：可測(cè)量動(dòng)態(tài)、靜態(tài)和各種波形的壓縮、張力、剪切和扭矩
可進(jìn)行高精度、多軸測(cè)試; 可在動(dòng)、靜和波形負(fù)載等多種模型中實(shí)現(xiàn)壓力、拉力、剪切及扭矩測(cè)試;
用戶友好的軟件用于高效的數(shù)據(jù)采集和簡(jiǎn)易的分析， 采集的數(shù)據(jù)可導(dǎo)入三方軟件進(jìn)一步分析。
專業(yè)服務(wù)團(tuán)隊(duì)為Mach-1產(chǎn)品的選擇， 實(shí)驗(yàn)方法準(zhǔn)備和各種附件設(shè)計(jì)提供支持。
Mach-1應(yīng)用領(lǐng)域：
皮膚彈性測(cè)試---軟組織彈性測(cè)試;
腳底面軟組織彈性--軟組織彈性測(cè)試;
纖維材料的彈性--材料彈性測(cè)試;
動(dòng)物毛發(fā)--材料彈性測(cè)試;
縫合傷口材料--材料彈性、壓力應(yīng)變測(cè)試;
凝膠表征--材料彈性、壓力、剪切應(yīng)變測(cè)試;
傷口愈合評(píng)定--材料彈性、壓力應(yīng)變測(cè)試;
藥片粘合實(shí)驗(yàn)--材料壓力、剪切應(yīng)變測(cè)試;
細(xì)胞組織培養(yǎng)物雙向模擬--材料壓力、剪切應(yīng)變測(cè)試;
關(guān)節(jié)軟骨修復(fù)評(píng)定--材料彈性、壓力、剪切應(yīng)變測(cè)試;
藻酸鹽微球力學(xué)評(píng)估--材料彈性、壓力、剪切應(yīng)變測(cè)試;
應(yīng)用文獻(xiàn)
Development of an Electromechanical Grade to Assess Human Knee Articular Cartilage QualitySim S, Chevrier A, Garon M, Quenneville E, Lavigne P and Buschmann MDAnn Biomed Eng. doi: 10.1007/s10439-017-1879-4. (2017)
Quantitative assessments of articular cartilage function are needed to aid clinical decision making. Our objectives were to develop a new electromechanical grade to assess quantitatively cartilage quality and test its reliability....
Read More
https://www.ncbi.nlm.nih.gov/pubmed/
Electromechanical probe and automated indentation maps are sensitive techniques in assessing early degenerated human articular cartilageSim S, Chevrier A, Garon M, Quenneville E, Lavigne P, Yaroshinsky A and Buschmann M DJournal of Orthopaedic Research, 35(4), 858-867.
Recent advances in the development of new drugs to halt or even reverse the progression of Osteoarthritis at an early-stage requires new tools to detect early degeneration of articular cartilage. We investigated the ability of an electromechanical probe... Read More /doi/10.1002/jor.23330/full
https://www.ncbi.nlm.nih.gov/pubmed/
Electromechanical properties of human osteoarthritic and asymptomatic articular cartilage are sensitive and early detectors of degenerationHadjab I, Sim S, Karhula S.S, Kauppinen S. Garon M, Quenneville E, Lavigne P, Lehenkari P.P and Buschmann MDOsteoarthritis Cartilage. doi: http://doi.org/10.1016/j.joca.2017.12.002. (2017)
Objective: To evaluate cross-correlations of ex vivo electromechanical properties with cartilage and subchondral bone plate thickness, as well as their sensitivity and specificity regarding early cartilage degeneration in human tibial plateau.
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Read More /science/article/pii/S1063458417313572
Evaluation of a novel technique to map the mechanical properties of an entire articular surface in indentationSim S, Quenneville E, Garon M, Hoemann CD, Hurtig M and Buschmann MDInternational Cartilage Repair Society (ICRS), Turkey, 2013, Podium presentation (11.2.9)
Purpose: Mechanical testing of articular cartilage is recommended by the FDA for products intended for the repair or replacement of knee cartilage. One experimental configuration that has many practical advantages is indentation. However, one limitation... Read More Sim-ICRS2013-Presentation.pdf
Validation of a surgical wound healing model in Sprague-Dawley ratsAuthier S, Fournier S, Chaurａnd F, Gordon C, Garon M, Cloutier L and Troncy EPaper presented at the 27th Annual Meeting of the American College of Toxicology (November 2006)
BACKGROUND: Wound healing is a biological process that can be altered by drugs in specific therapeutic classes. The aim of the study was to validate a wound healing rat model with tensile strength measurements.
MATERIALS...
Read More Authier-ACT2006_Wound_Healing-Poster.pdf
Assessment of Human Articular Cartilage Issued from Asymptomatic & TKR DonorsHadjab I, Sim S, Quenneville E, Garon M and Buschmann MDBiomedical Engineering Society 2015 in Tampa, Floride
Introduction: Cartilage degeneration is a progressive process and currently, only end-stage surgical treatments such as total knee replacement (TKR) lead to an improved condition. To prevent or delay this surgery, several less invasive alternatives... Read More
Guided subchondral bone marrow stimulation through a novel biomaterial microparticle approachHoemann C, Guzman-Morales J, Chen G, Picard G, Veilleux D, Sim S, Garon M, Quenneville E, Buschmann MD, Lafantaisie-Favreau CH and Hurtig MPresentation #335.2 on Fri May 20 from 16:30 to 18:15 in Room 516C at World Congress on Biomechanics, Montreal, May 2016
Hyaline-like cartilage repair can be occasionally elicited by bone marrow stimulation procedures however mainly in younger patients, indicating the need for further treatments to improve success rates in middle-aged patients. Traditional scaffold-guided... Read More http://mywbc.org/lectures/view/4119
Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritis Mice Using IndentationLavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CE2015 International Cartilage Repair Society, May 7-11 2015, Chicago, Illinois, USA. Podium presentation (ID: 23.2.9)
Purpose: Due to their size (~1mm), mouse models pose significant challenges to map biomechanical properties over their articular surfaces. The purpose of this study was to determine if an automated indentation technique could be used to map the... Read More Lavoie-2015B-ICRS-Presentation.pdf
Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritic Mice Using IndentationLavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CEOsteoarthritis Research Society International (OARSI), 2015 April 30, Seattle, WA, United States
Purpose: Due to their size (~1mm), mouse models pose significant challenges to map biomechanical properties over their articular surfaces. The purpose of this study was to determine if an automated indentation technique could be used to map... Read More Lavoie-2015c-ICRS-Abstract.pdf
Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritic Mice Using IndentationLavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CEOsteoarthritis and Cartilage 23 Suppl. 2, p. A254 (2015)
Purpose: Due to their size (~1mm), mouse models pose significant challenges to map biomechanical properties over their articular surfaces. The purpose of this study was to determine if an automated indentation technique could be used to map the... Read More Lavoie-2015E.pdf
Novel Technique to Map the Biomechanical Properties of Entire Mice Articular Surfaces Using IndentationSim S, Lavoie JF, Moreau A, Quenneville E, Garon M, and Buschmann MDOsteoarthritis and Cartilage, 22(1), 541. World Congress on Osteoarthritis, April 2014, Paris, France.
Purpose: An important measure of articular cartilage function in health and disease is its biomechanical properties. While much research has mouse models of osteoarthritis, the assessment of biomechanical properties in these small joints is quite... Read More Sim-OARSI2014-Poster.pdf
Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Degenerated (Osteoarthritis-like) CartilageSim S, Chevrier A, Garon M, Quenneville E and Buschmann MD7th World Congress on Biomechanics, 2014, Boston, MA, USA. Poster 2229
Introduction: A currently unsatisfied need in Arthritis and cartilage research is to assess the function of the entire articular cartilage surface both quantitatively and non-destructively. The objective of this study was to investigate the ability... Read More Sim-2014e-WCB2014-Poster.pdf
Sim-2014d-ICoBT2014-Presentation.pdf
Indentation Method to Map Mechanical Properties of Articular Surface to Identify Degenerated RegionsSim S, Chevrier A, Garon M, Quenneville E and Buschmann MD2014 Annual Meeting of the Biomedical Engineering Society, 2014, San Antonio, TX, USA. Podium presentation (ID: OP-Sat-3-4)
Introduction: The identification and quantitative grading of early degenerated regions over an entire articular surface remains a challenging quest. The objective of this study was to investigate the ability of a novel technique to automatically... Read More Sim-2014g-abstract.pdf
Sim-2014G (BMES2014 Presentation).pdf
Correlation of Non-destructive Electromechanical Probe (Arthro-BST) Assessment with Histological Scores and Mechanical Properties in Human Tibial PlateauSim S, Chevrier A, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Las Vegas, 2015, Poster 1228
The purpose of the study was to investigate if electromechanical properties of human tibial plateau correlate strongly with histological scores and with biomechanical properties as in human distal femurs (Sim et al., 2014). Six pairs of tibial plateau... Read More Sim-2015a-ORS2015-Poster.pdf
Relevance of the Spatial Distribution of Mechanical Properties of Articular Cartilage in Animal StudiesSim S, Hadjab I, Garon M, Quenneville E, and Buschmann MDOrthopeadic Research Society Annual Meeting in Las Vegas, 2015, Poster 0359
Introduction: In cartilage regeneration and repair, mechanical testing of articular cartilage characterizes functional restoration of the repair site [1] and can detect early degeneration of articular cartilage [2]. However, the experimental design... Read More Sim-2015b-ORS2015-Poster.pdf
Sim-2015E-ICRS-Presentation.pdf
Evaluation of Entire Ovine Cartilage Repair Articular Surfaces: Mechanical and Electromechanical AssessmentSim S, Hadjab I, Garon M, Quenneville E, Hurtig MB, Buschmann MD and Hoemann CDTransactions of International Cartilage Repair Society (ICRS), Chicago, 2015, 7-11 May 2015, e-Poster: P87
Purpose: To demonstrate the ability of non-destructive electromechanical device and automated indentation technique in assessing the quality of cartilage in a sheep model of cartilage repair.
Methods: Ex vivo electromechanical... Read More Sim-2015F-ICRS-Abstract.pdf
Sim-2015F-ICRS-ePoster.pdf
Sim-2015F-ICRS-Poster.pdf
Wound Healing Revealed by a Novel Automated Indentation TechniqueSim S, Garon M, Quenneville E and Buschmann MDCanadian Connective Tissue Conference 2015 in Quebec, Canada
Introduction: Mechanical characterization of wound healing in skin samples mostly relies on uniaxial tensile rupture tests, which provide local information along the wound and are disruptive for samples (Chao et al., 2011). In this study, we wanted... Read More Sim-2015H-CCTC-Presentation.pdf
Sim-2015H-CCTC-Abstract-with-images.pdf
Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrａnd A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016
In a recent study, our group has highlighted the importance of considering the natural topographic variability of the mechanical properties over the articular surface, particularly in the context of cartilage repair, where it can screen the effect of... Read More Sim-2016A-ORS2016-Poster.pdf
Cartilage Stiffness and Thickness Distributions Revealed by an Automated Indentation Technique in the Temporomandibular JointSim S, Matuska A, Garon M, Quenneville E, McFetridge P and Buschmann MDTMJ Bioengineering Conference - V, September 12-13, 2016, Barcelona, Spain
The purpose of this study was to evaluate the capability of an automated indentation technique to reveal the topographical variation of mechanical properties over the entire articular surface of the temporomandibular joint (TMJ), especially the thickness... Read More Sim-2016B (TMJ Bioengineering 2016 Abstract Proof).pdf
Sim-2016B (TMJ Bioengineering 2016 Presentation).pptx
Correlation of Non-destructive Electromechanical Probe (Arthro-BST) Assessment with Histological Scores, Biochemical Composition and Mechanical Properties in Human Knee JointsSim S, Chevrier A, Quenneville E, Garon M and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA, Poster 0439, 2014
Introduction: Histological scoring, biochemical analyses and biomechanical testing (unconfined compression) are often seen as gold standard characterizations for articular cartilage but can present major drawbacks in the context of animal and human... Read More Sim-ORS2014a.pdf
Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Osteoarthritis-like RegionsSim S, Chevrier A, Garon M, Quenneville E and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, 2014, New Orleans, LA, USA, 2015, Poster #2015
Introduction: It is challenging to identify and grade degenerated regions of the entire articular surface both quantitatively and non-destructively. Therefore, the objective of this study was to investigate the ability of a novel technique to automatically... Read More Sim-ORS2014b.pdf
Age-dependence of the Pattern of Cartilage Electromechanical Properties in the Ovine Stifle JointSim S, Picard G, Quenneville E, Garon M and Buschmann MDTransactions of the 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX, USA, 2013.
Introduction: The biochemical composition and mechanical/electromechanical properties of articular cartilage evolve during growth. The objective of this study was to examine the age-dependence in the distribution pattern of electromechanical properties... Read More Sim-2013b-Poster.pdf
Streaming Potential-Based Arthroscopic Device Can Detect Changes Immediately Following Localized Impact in an Equine Impact Model of OsteoarthritisChangoor A, Quenneville E, Garon M, Hurtig MB and Buschmann MDOsteoarthritis and Cartilage, Vol. 17, Supplement 1, S53, World Congress on Osteoarthritis, September 2009, Montreal, Quebec, Canada. (2009)
Early Post-traumatic Osteoarthritis (PTOA) can be asymptomatic but represents a possible window of opportunity for therapeutic intervention before disease progression. Impact models are ideal for studying these strategies because the location and severity... Read More Changoor-OARSI2009-poster.pdf
Comparison Between In Vitro and Simulated Arthroscopy Electromechanical Measurements of Human Articular Surfaces Using the Arthro-BSTSim S, Becher C, Garon M, Quenneville E, Hurschler C and Buschmann MDInternational Cartilage Repair Society 2016 in Sorrento, Italy. Poster 132
Purpose: The output of the Arthro-BST was originally streaming potentials integral (SPI) parameter (Abedian-2013). Since then, the output has changed to a quantitative parameter (QP) (Sim-2014). The purpose of this study was to reanalyzed old data... Read More Sim-2016C (ICRS2016 Poster).pdf
Sim-2016C (ICRS2016 Abstract Proof).pdf
Sim-2016C (ICRS2016 ePoster).pdf
/icrs2016/confcal/quenneville
The Verification of the Mechanical Properties of Binder Jetting Manufactured Parts by Instrumented Indentation TestingZhou Y, Tang Y, Hoff T, Garon M and Fiona Yaoyao Zhao43rd Proceedingsof the North American Manufacturing Research. Volume 1, Pages 327–342. (2014)
In order to figure out the mechanical properties of free form biomedical parts made by Additive Manufacturing (AM), Instrumented Indentation Testing (IIT) is introduced to measure the Young’s modulus from the free surface of the parts. The research... Read More /publication/283958401_The_Verification_of_the_Mechanical_Properties_of_Binder_Jetting_Manufactured_Parts_by_Instrumented_Indentation_Testing
Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage DegenerationSim S, Hadjab I, Chevrolat L-A, Masse M, Tong AL, Lavigne P, Garon M, Quenneville E and Buschmann MDAccepted for a podium presentation at ORS 2017
Introduction: We published a recent study showing superior sensitivity of electromechanical and indentation (instantaneous response) assessments versus well-established techniques, including histological Mankin score, to characterize cartilage... Read More Sim-2017A (ORS2017 Abstract Proof).pdf
Non-destructive electromechanical assessment (Arthro-BST) of human articular cartilage correlates with histological scores and biomechanical propertiesSim S, Chevrier A, Garon M, Quenneville E, Yaroshinsky A, Hoemann CD and Buschmann MDOsteoarthritis Cartilage, 22(11) 1926-35. (2014)
OBJECTIVE:The hand-held Arthro-BST device is used to map electromechanical properties...
Read More
https://www.ncbi.nlm.nih.gov/pubmed/
Electromechanical probe and automated indentation maps are sensitive techniques in assessing early degenerated human articular cartilageSim S, Chevrier A, Garon M, Quenneville E, Lavigne P, Yaroshinsky A, Hoemann CD and Buschmann MDJ Orthop Res, 35(4) 858-867. (2017) Epub 2016 Jun 22
Recent advances in the development of new drugs to halt or even reverse the progression...
Read More
https://www.ncbi.nlm.nih.gov/pubmed/
Freeze-Dried Chitosan-PRP Injectable Surgical Implants for Meniscus Repair: Pilot Feasibility Studies in Ovine ModelsGhazi Zadeh L, Chevrier A, Hurrtig MB, Farr J, Rodeo S, Hoemann CD and Buschmann MDRegen Med Ther, 1(1) 16-29. (2017)
Clinical management of meniscus tears often involves partial meniscectomy, which can lead to Osteoarthritis (OA). Meniscus repair augmentation strategies are being developed to compensate for the tissue’s limited healing response. The purpose of... Read More https://thescipages.org/Articles/regenerative-medicine/rmt-1-002.pdf
The effect of two nonresorbable suture types on the mechanical performance over a metal suture anchor eyeletActon D, Perry A, Evans R, Butler A, Stephens P, Bruce W, Goldberg J, Sonnabend D and Walsh WKnee Surgery, Sports Traumatology, Arthroscopy, 2004, 12(2), 165-168
An understanding of the mechanical properties of different suture materials is valuable when selecting the most appropriate suture and repair technique. Sutures should be strong, easy to handle and have high knot security. The introduction of suture anchors... Read More /publication/9886886_The_effect_of_two_nonresorbable_suture_types_on_the_mechanical_performance_over_a_metal_suture_anchor_eyelet
Heightened aberrant deposition of hard-wearing elastin in conduit arteries of prehypertensive SHR is associated with increased stiffness and inward remodelingArribas SM, Briones AM, Bellingham C, Gonzalez MC, Salaices M, Liu K, Wang Y and Hinek AAm J Physiol Heart Circ Physiol, 2008, 295(6), H2299-2307
Elastin is a major component of conduit arteries and a key determinant of vascular viscoelastic properties. Aberrant organization of elastic lamellae has been reported in resistance vessels from spontaneously hypertensive rats (SHR) before the... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Sensitivity of indentation testing to step-off edges and interface integrity in cartilage repairBae W, Law A, Amiel D and Sah RAnn Biomed Eng, 32(3), 360-369. (2004)
Step-off edges and tissue interfaces are prevalent in cartilage injury such as after intra-articular fracture and reduction, and in focal defects and surgical repair procedures such as osteochondral graft implantation. It would be useful to assess the... Read More
Indentation probing of human articular cartilage: effect on chondrocyte viabilityBae W, Schumacher B and Sah ROsteoarthritis and Cartilage, 15(1), 9-18. (2007)
BACKGROUND: Clinical arthroscopic probes based on indentation testing are being developed. However, the biological effects of certain design parameters (i.e., tip geometry and size) and loading protocols (i.e., indentation depth, rate, and repetition)... Read More
Novel fluoro-terpolymers for coatings applicationsBaradie B and Shoichet MS.Macromolecules, 38(13), 5560-5568. (2005)
A series of thermally stable, elastomeric and hydrophobic fluoro-terpolymers of tetrafluoroethylene (TFE), vinyl acetate (VAc), and poly(dimethylsiloxane) methyl acrylate-terminated (PDMSMA), P(TFE-ter-VAc-ter-PDMSMA), were synthesized in supercritical... Read More /doi/full/10.1021/ma047792s
Biomechanical models for radial distance determination by the rat vibrissal systemBirdwell JA, Solomon JH, Thajchayapong M, Taylor MA, Cheely M, Towal RB, Conradt J and Hartmann MJJournal of neurophysiology, 98(4), 2439-2455. (2007)
Rats use active, rhythmic movements of their whiskers to acquire tactile information about three-dimensional object features. There are no receptors along the length of the whisker; therefore all tactile information must be mechanically transduced back... Read More /content/98/4/2439
A comparative biomechanical analysis of term fetal membranes in human and domestic speciesBorazjani A, Weed BC, Patnaik SS, Feugang JM, Christiansen D, Elder SH, Ryan PL and Liao JAmerican journal of obstetrics and gynecology, 204(4), 365. e325-365. e336. (2011)
OBJECTIVE: The purpose of this study was to biomechanically characterize and compare human, porcine, equine, and ovine fetal membranes.
STUDY DESIGN: Noncontact metrology was used for topographic analyses.... Read More
Tensile properties in collagen-rich tissues of Quarter Horses with hereditary equine regional dermal asthenia (HERDA)Bowser J, Elder S, Pasquali M, Grady J, Rashmir-Raven A, Wills R and Swiderski CEquine Vet J. 2014 Mar;46(2):216-22. doi: 10.1111/evj.12110. Epub 2013 Aug 30.
REASONS FOR PERFORMING STUDY: Hereditary equine regional dermal asthenia (HERDA) is an autosomal recessive disorder of Quarter Horses characterised by skin fragility. Horses with HERDA have a missense mutation in peptidyl-prolyl cis-trans isomeraseB... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Development and Validation of Large-Sized Engineering Cartilage Constructs in Full-Thickness Chondral Defects in a Rabbit ModelBrenner JMaster thesis Queen's University. (2012)
Long-term applicability of current surgical interventions for the repair of articular cartilage is jeopardized by the formation of mechanically inferior repair tissue. Cartilage tissue engineering offers the possibility of developing functional repair... Read More /1974/6988
Development of large engineered cartilage constructs from a small population of cellsBrenner JM, Kunz M, Tse MY, Winterborn A, Bardana DD, Pang SC and Waldman SDBiotechnology progress, 29(1), 213-221. (2013)
Confronted with articular cartilage's limited capacity for self-repair, joint resurfacing techniques offer an attractive treatment for damaged or diseased tissue. Although tissue engineered cartilage constructs can be created, a substantial number... Read More
Mechanical response of ankle ligaments at low loadsButler AM and Walsh WRFoot & ankle international, 25(1), 8-12. (2004)
BACKGROUND: The aim of this study was to examine the mechanical behavior of human ankle ligaments at low forces. Predominantly, ankle ligaments have been studied under the auspices of ligament injury. While the mechanical properties of a ligament... Read More
Assessment of a Regenerative Therapy Strategy for Chondral Defects in Articular CartilageCarroll AThesis Queen’s University, 2015
Osteoarthritis is one of the leading causes of disability in adults over the age of 40 years, and there is currently no curative measure for the disease. As a result, there is a critical need for a strategy that can promote cartilage regeneration. Of... Read More /1974/13628
Association of 3-dimensional cartilage and bone structure with articular cartilage properties in and adjacent to autologous osteochondral grafts after 6 and 12 months in a goat modelChan EF, Liu IL, Semler EJ, Aberman HM, Simon TM, Chen AC, Truncale KG and Sah RLCartilage, 3(3), 255-266. (2012)
The articular cartilage of autologous osteochondral grafts is typically different in structure and function from local host cartilage and thereby presents a remodeling challenge. The hypothesis of this study was that properties of the articular cartilage... Read More /content/3/3/255.abstract
A new radiopaque embolizing agent for the treatment of endoleaks after endovascular repair: Influence of contrast agent on chitosan thermogel propertiesCoutu JM, Fatimi A, Berrahmoune S, Soulez G and Lerouge SJournal of Biomedical Materials Research Part B: Applied Biomaterials, 101(1), 153-161. (2013)
A new injectable radiopaque embolizing agent has been developed, based on chitosan thermogelling properties. Different commercial contrast agents (Isovue®, Visipaque®, and Conray®) were associated with chitosan--glycerophosphate. Their impact on gelation... Read More http://espace.etsmtl.ca/970/
Enhanced mechanical properties in cellulose nanocrystal-poly(oligo ethylene glycol methacrylate) injectable nanocomposite hydrogels through control of physical and chemical cross-linkingDe France KJ, Chan K.J.W, Cranston ED and Hoare TBiomacromolecules. 2016 Feb 8;17(2):649-60. doi: 10.1021/acs.biomac.5b01598. Epub 2016 Jan 15.
While injectable hydrogels have several advantages in the context of biomedical use, their generally weak mechanical properties often limit their applications. Herein, we describe in situ-gelling nanocomposite hydrogels based on poly(oligoethylene glycol... Read More /doi/10.1021/acs.biomac.5b01598
https://www.ncbi.nlm.nih.gov/pubmed/
Determining the modulus of intact bovine vertebral cancellous bone tissue: Development and validation of a protocolEngbretson ACMaster thesis Queen's University. (2010)
Cancellous, or spongy, bone accounts for nearly 80% of the human skeleton’s internal surface area, despite comprising only 20% of its mass. It is made up of a network of struts and plates that provide lightweight internal support to mammalian bones.... Read More http://qspace.library.queensu.ca/bitstream/1974/5993/1/Engbretson_Andrew_C_201008_MASc.pdf.pdf
Tuning the Microenvironment: Click-Crosslinked Hyaluronic Acid-Based Hydrogels Provide a Platform for Studying Breast Cancer Cell InvasionFisher SA, Anandakumaran PN, Owen SC and Shoichet MSAdv. Funct. Mater. 2015. DOI: 10.1002/adfm.201502778
A big challenge in cell culture is the non-natural environment in which cells are routinely screened, making in vivo phenomena, such as cell invasion, difficult to understａnd and predict. To study cancer cell invasion, extracellular matrix (ECM) analogs... Read More http://www.ecf.utoronto.ca/~molly/publications/tuning%20the%20microenvironment...breast%20cancer%20cell%20invasion%20(in%20press).pdf
Development of scaffold-free elastic cartilaginous constructs with structural similarities to auricular cartilageGiardini-Rosa R, Joazeiro PP, Thomas K, Collavino K, Weber J and Waldman SDTissue Engineering Part A. Volume 20, Numbers 5 and 6, 2014, pp 1012-26 (2014)
External ear reconstruction with autologous cartilage still remains one of the most difficult problems in the fields of plastic and reconstructive surgery. As the absence of tissue vascularization limits the ability to stimulate new tissue growth, relatively... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Injectable Interpenetrating Network Hydrogels via Kinetically Orthogonal Reactive Mixing of Functionalized Polymeric PrecursorsGilbert T, Smeets NMB and Hoare TACS Macro Letters, 2015, 4, 1104-1109.
The enhanced mechanics, unique chemistries, and potential for domain formation in interpenetrating network (IPN) hydrogels have attracted significant interest in the context of biomedical applications. However, conventional IPNs are not directly injectable... Read More /doi/abs/10.1021/acsmacrolett.5b00362
Evaluation of a bioabsorable polylactide film in a large animal model for the reduction of retrosternal adhesionsIliopoulos J, Cornwall G, Evans R, Manganas C, Thomas K, Newman D and Walsh WJournal of Surgical Research, 118(2), 144-153. (2004)
OBJECTIVES: An adult pig model of retrosternal adhesion formation via an inferior hemisternotomy was used to evaluate the formation and development of pericardial and retrosternal adhesions, as well as adhesion reduction using two thicknesses of... Read More https://www.ncbi.nlm.nih.gov/pubmed/
The Aortic Wrap Procedure - A Surgical Method of Treating Age-Related Aortic Dilatation and StiffnessIliopoulos JPhD Thesis, University of New South Wales, Sydney. (2006)
Introduction: There is progressive stiffening and dilatation of the aorta and large elastic arteries with aging as a result of the repetitive cyclic stress they are exposed to throughout life. Aortic stiffening has a number of detrimental effects... Read More http://www.unsworks.unsw.edu.au/primo_library/libweb/action/dlDisplay.dovid=UNSWORKS&docId=unsworks_1296
Shear mechanics of the TMJ disc - relationship to common clinical observationsJuran CM, Dolwick MF, and McFetridge PSJ Dent Res. 2013 Feb, 92(2):193-8.
The temporomandibular joint (TMJ) is a complex hinge and gliding joint that induces significant shear loads onto the fibrocartilage TMJ disc during jaw motion. The purpose of this study was to assess regional variation in the disc's shear loading... Read More http://www.ncbi.nlm.nih.gov/pubmed/term=Shear+Mechanics+of+the+TMJ+Disc%3A+Relationship+to+Common+Clinical+Observations
/publication/233724951_Shear_Mechanics_of_the_TMJ_Disc_Relationship_to_Common_Clinical_Observations
Micro-CT visualization and indentation properties of whole meniscus following mercury exposureKolaczek S, Changoor A, Hurtig M, Gordon K and Getgood AAnnual Meeting of the ORS, New Orleans, Louisiana, USA, March 15-18, 2014.
A major risk factor for knee osteoarthritis (OA) is meniscal injury or excision. Surgeons now advocate for meniscal repair or allografts rather than excision with this knowledge in hand. Clinical assessment of the meniscal load sharing is limited to... Read More http://prgapps.com/AppUpdates/ors/Abstracts/abs1330.html
Engineering of Hyaline Cartilage with a Calcified Zone Using Bone Marrow Stromal CellsLee WD, Hurtig MB, Pilliar RM, Stanford WL and Kandel RAOsteoarthritis and Cartilage (2015), doi: 10.1016/j.joca.2015.04.010
In healthy joints, a zone of calcified cartilage (ZCC) provides the mechanical integration between articular cartilage and subchondral bone. Recapitulation of this architectural feature should serve to resist the constant shear force from the movement... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Soft Tissue Phantoms for Realistic Needle Insertion - A Comparative StudyLeibinger A, Forte AE, Tan Z, Oldfield MJ, Beyrau F, Dini D and Rodriguez y Baena FAnnals of Biomedical Engineering. pp 1-11 (2015)
Phantoms are common substitutes for soft tissues in biomechanical research and are usually tuned to match tissue properties using standard testing protocols at small strains. However, the response due to complex tool-tissue interactions can differ depending... Read More /article/10.1007/s10439-015-1523-0/fulltext.html
Characterization of the effect of microfracture surgery and angle of incidence on the structural properties of femoral boneLiang LD, Wagner A, Steeds J, Hurtig M and Gordon KStudies by Undergraduate Researchers at Guelph, 7(1), 56-61. (2013)
Microfracture surgery is one of the most common treatment options for knee osteoarthritis, a chronic inflammatory disease of the knee joint. However, a recent study by Theodoropoulos et al. (2012) has shown that there are significant variations in the... Read More https://journal.lib.uoguelph.ca/index.php/surg/article/view/2848
Effects of demineralized bone matrix on tendon-bone healing in an intra-articular rodent modelLovric V, Chen D, Yu Y, Oliver RA, Genin F and Walsh WRThe American journal of sports medicine, 40(10), 2365-2374. (2012)
BACKGROUND: Techniques to improve and accelerate tendon-bone healing could be advantageous in anterior cruciate ligament (ACL) reconstruction. Effects of demineralized bone matrix (DBM) on intra-articular tendon-bone healing have not been examined.<>
Read More https://www.ncbi.nlm.nih.gov/pubmed/
The effect of terminal sterilization on structural and biophysical properties of a decellularized collagen-based scaffold; implications for stem cell adhesionMatuska AM and McFetridge PSJ Biomed Mater Res Part B, 2014, pp 1-10
Terminal sterilization induces physical and chemical changes in the extracellular matrix (ECM) of ex vivo-derived biomaterials due to their aggressive mechanism of action. Prior studies have focused on how sterilization affects the mechanical integrity... Read More https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443929/
Biomechanical and biochemical outcomes of porcine temporomandibular joint disc deformationMatuska AM, Muller S, Dolwick MF and McFetridge PSArchives of Oral Biology. 64, 2016, 72–79
Objective: The structure–function relationship in the healthy temporomandibular joint (TMJ) disc has been well established, however the changes in dysfunctional joints has yet to be systematically evaluated. Due to the poor understanding of the... Read More
In vivo dynamic loading reduces bone growth without histomorphometric changes of the growth plateMenard AL, Grimard G, Valteau B, Londono I, Moldovan F and Villemure IJ Orthop Res. 2014 Sep;32(9):1129-36. doi: 10.1002/jor.22664. Epub 2014 Jun 6.
This in vivo study aimed at investigating the effects of dynamic compression on the growth plate. Rats (28 days old) were divided into three dynamically loaded groups, compared with two groups (control, sham). A device was implanted on the 6th and 8th... Read More http://www.ncbi.nlm.nih.gov/pubmed/
/publication/262931706_In_Vivo_Dynamic_Loading_Reduces_Bone_Growth_Without_Histomorphometric_Changes_of_the_Growth_Plate
Static and Dynamic Compression Application and Removal on the Intervertebral Discs of Growing RatsMenard AL, Grimard G, Massol E, Londono I, Moldovan F and Villemure IJournal of Orthopaedic Research Month 2015, pp.1-9. (2015)
Fusionless implants are used to correct pediatric progressive spinal deformities, most of them spanning the intervertebral disc. This study aimed at investigating the effects of in vivo static versus dynamic compression application and removal on discs... Read More http://www.ncbi.nlm.nih.gov/pubmed/
Bone growth resumption following in vivo static and dynamic compression removals on ratsMenard AL, Grimard G, Londono I, Beaudry F, Vachon P, Moldovan F and Villemure IBone. 81 pp. 662-8 doi: 10.1016/j.bone.2015.09.013. (2015)
Mechanical loadings influence bone growth and are used in pediatric treatments of musculoskeletal deformities. This in vivo study aimed at evaluating the effects of static and dynamic compression application and subsequent removal on bone growth, mineralization... Read More http://www.ncbi.nlm.nih.gov/pubmed/
Hyaluronic acid click hydrogels emulate the extracellular matrixOwen SC, Fisher SA, Tam RY, Nimmo CM and Shoichet MSLangmuir, 29(24), 7393-7400. (2013)
Hydrogels are used to create 3D microenvironments with properties that direct cell function. The current study demonstrates the versatility of hyaluronic acid (HA)-based hydrogels with independent control over hydrogel properties such as mechanics, architecture,... Read More /doi/abs/10.1021/la305000w
https://www.ncbi.nlm.nih.gov/pubmed/
The shear mechanical properties of diabetic and non-diabetic plantar soft tissuePai S and Ledoux WRJournal of biomechanics, 45(2), 364-370. (2012)
Changes in the plantar soft tissue shear properties may contribute to ulceration in diabetic patients, however, little is known about these shear parameters. This study examines the elastic and viscoelastic shear behavior of both diabetic and non-diabetic... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Longitudinal Stent Deformation: Importance of Stent Type and Stent AppositionPitne, M, van Niekerk E, Dokos S, Pelletier M and Walsh WRAmerican Journal of Biomedical Engineering, 3(3), 63-69. (2013)
Information on stent longitudinal strength is limited to benchtop models using unconstrained stents, consequently having uncertain clinical significance. This study investigated the effects of stent apposition and tube (artery) compliance on stent stability.... Read More /10.5923.j.ajbe..03.html
Low Magnitude High Frequency Vibration Accelerated Cartilage Degeneration but Improved Epiphyseal Bone Formation in Anterior Cruciate Ligament Transect Induced Osteoarthritis Rat ModelQin J, Chow S KH, Guo A, Wong WN., Leung KS and Cheung WHOsteoarthritis and Cartilage. July 2014, Vol.22(7):1061–1067. (2014)
Objectives: To evaluate the effects of low-magnitude high-frequency vibration (LMHFV) on degenerated articular cartilage and subchondral bone in anterior cruciate ligament transection (ACLT) induced osteoarthritis (OA) rat model. <>
Read More /science/article/pii/S1063458414010838
Growth Factor Stimulation Improves the Structure and Properties of Scaffold-Free Engineered Auricular Cartilage ConstructsRosa RG, Joazeiro PP, Bianco J, Kunz M, Weber JF, et alPLoS ONE 9(8): e105170. doi:10.1371/journal.pone.0105170. (2014)
The reconstruction of the external ear to correct congenital deformities or repair following trauma remains a significant challenge in reconstructive surgery. Previously, we have developed a novel approach to create caffold-free, tissue engineering elastic... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Tissue engineered nucleus pulposus tissue formed on a porous calcium polyphosphate substrateSeguin CA, Grynpas MD, Pilliar RM, Waldman SD and Kandel RASpine, 29(12), 1299-1306. (2004)
STUDY DESIGN: This study describes the formation of nucleus pulposus tissue using a novel tissue engineering approach. OBJECTIVES: To determine if a construct composed of nucleus pulposus tissue on the surface of a calcium polyphosphate substrate... Read More https://www.ncbi.nlm.nih.gov/pubmed/
/publication/8518908_Tissue_Engineered_Nucleus_Pulposus_Tissue_Formed_on_a_Porous_Calcium_Polyphosphate_Substrate
Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null miceSuen RS, Rampersad SN, Stewart DJ and Courtman DWThe American journal of pathology, 179(3), 1549-1559. (2011)
Because both endothelin-1 (ET-1) and angiotensin II (AngII) are independent mediators of arterial remodeling, we sought to determine the role of ET receptor inhibition in AngII-accelerated atherosclerosis and aortic aneurysm formation. We administered... Read More https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157254/
Elastic modulus of 316 stainless steel lattice structure fabricated via binder jetting processTang Y, Zhou Y, Hoff T, Garon M and Zhao FYMaterials Science and Technology 32(7):1743284715Y.000 · June 2015 DOI: 10.1179/1743284715Y.0000000084
This study mainly evaluates the elastic modulus of 316 stainless steel lattice structures fabricated via binder jetting process. In this present research, both solid and lattice samples are designed and fabricated by binder jetting process for two different... Read More /doi/10.1179/1743284715Y.0000000084
/publication/279157683_Elastic_modulus_of_316_stainless_steel_lattice_structure_fabricated_via_binder_jetting_process
Experimental Evidence of Mechanical Isotropy in Porcine Lung ParenchymaWeed B, Patnaik S, Rougeau-Browning M, Brazile B, Liao J, Prabhu R and Williams LNMaterials 2015, 8 , 2454-2466; doi:10.3390/ma8052454
Pulmonary injuries are a major source of morbidity and mortality associated with trauma. Trauma includes injuries associated with accidents and falls as well as blast injuries caused by explosives. The prevalence and mortality of these injuries has made... Read More /publication/276518603_Experimental_Evidence_of_Mechanical_Isotropy_in_Porcine_Lung_Parenchyma
Injectable Interpenetrating Network Hydrogels via Kinetically Orthogonal Reactive Mixing of Functionalized Polymeric PrecursorsTrevor G, Niels M. B. Smeets and Hoare TACS Macro Letters, September 16, 2015, 1104–9. doi:10.1021/acsmacrolett.5b00362
The enhanced mechanics, unique chemistries, and potential for domain formation in interpenetrating network (IPN) hydrogels have attracted significant interest in the context of biomedical applications. However, conventional IPNs are not directly injectable... Read More /10.1021/acsmacrolett.5b00362
Defective Bone Mineralization and Osteopenia in Young Adult Fgfr3-/- MiceValverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D, Ornitz DM and Henderson JEHum Mol Genet, 13(3), 271-284
Mutations that cause constitutive activation of fibroblast growth factor receptor 3 (FGFR3) result in skeletal disorders that are characterized by short-limbed dwarfism and premature closure of cranial sutures. In previous work, it was shown that congenital... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient miceValverde-Franco G, Binette JS, Li W, Wang H, Chai S, Laflamme F, Tran-Khanh N, Quenneville E, Meijers T, Poole AR, Mort JS, Buschmann MD and Henderson JEHuman molecular genetics, 15(11), 1783-1792. (2006)
Fibroblast growth factor (FGF) receptor 3 has been identified as a key regulator of endochondral bone development and of post-natal bone metabolism through its action on growth plate chondrocytes and osteoblasts, respectively. It has also been shown to... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Stochastic resonance is a method to improve the biosynthetic response of chondrocytes to mechanical stimulationWeber JF and Waldman SDJournal of Orthopaedic Research 08/2015; DOI:10.1002/jor.23000
Cellular mechanosensitivity is an important factor during the mechanical stimulation of tissue engineered cartilage. While the application of mechanical stimuli improves tissue growth and properties, chondrocytes also rapidly desensitize under prolonged... Read More
The Effects of Oxidative Stress on the Compressive Damage Thresholds of C2C12 Mouse Myoblasts: Implications for Deep Tissue InjuryYao Y, Xiao Z, Wong S, Hsu YC, Cheng T, Chang CC, Bian L and Mak AFAnn Biomed Eng. 2015 Feb;43(2):287-96. doi: 10.1007/s10439-014-1239-6. Epub 2015 Jan 6.
Deep tissue injury (DTI) is a severe kind of pressure ulcers formed by sustained deformation of muscle tissues over bony prominences. As a major clinical issue, DTI affects people with physical disabilities, and is obviously related to the load-bearing... Read More https://www.ncbi.nlm.nih.gov/pubmed/
/publication/270596382_The_Effects_of_Oxidative_Stress_on_the_Compressive_Damage_Thresholds_of_C2C12_Mouse_Myoblasts_Implications_for_Deep_Tissue_Injury
Experimental Investigation of Mechanical and Thermal Properties of Silica Nanoparticle-Reinforced Poly(acrylamide) Nanocomposite HydrogelsZaragoza J, Babhadiashar N, O’Brien V, Chang A, Blanco M, Zabalegui A, H Lee and Asuri PPLoS ONE 10(8): e0136293. doi:10.1371/journal. pone.0136293. (2015)
Current studies investigating properties of nanoparticle-reinforced polymers have shown that nanocomposites often exhibit improved properties compared to neat polymers. However, over two decades of research, using both experimental studies and modeling... Read More http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547727/
Infarcted rat myocardium: Data from biaxial tensile and uniaxial compressive testing and analysis of collagen fibre orientationSirry MS, Butler JR, Patnaik SS, Brazile B, Bertucci R, Claude A, McLaughlin R, Davies NH and Liao JData in Brief 8 (2016) 1338–1343
Myocardial infarction was experimentally induced in rat hearts and harvested immediately, 7, 14 and 28 days after the infarction induction. Anterior wall infarct samples underwent biaxial tensile and uniaxial compressive testing. Orientation of collagen... Read More /publication/305922724_Infarcted_rat_myocardium_Data_from_biaxial_tensile_and_uniaxial_compressive_testing_and_analysis_of_collagen_fibre_orientation
A composite hydrogel for brain tissue phantomsForte AE, Galvan S, Manieri F,y Baena FR and Dini DMaterials & Design, 112, 227-238 (2016)
Synthetic phantoms are valuable tools for training, research and development in traditional and computer aided surgery, but complex organs, such as the brain, are difficult to replicate. Here, we present the development of a new composite hydrogel capable... Read More /S0264127516312370/1-s2.0-S0264127516312370-main.pdf_tid=0a46be54-8b1f-11e6-a1e0-00000aab0f26&acdnat=1475687791_980f587a916a30065ad493e138d771b0
Biomechanical Characterisation of the Human Auricular Cartilage - Implications for Tissue EngineeringGriffin MF, Premakumar Y, Seifalian M, Szarko and Butler PEMAnnals of Biomedical Engineering, 2016. Punlished online, 14Jul2016. DOI: 10.1007/s10439-016-1688-1
Currently, autologous cartilage provides the gold standard for auricular reconstruction. However, synthetic biomaterials offer a number of advantages for ear reconstruction including decreased donor site morbidity and earlier surgery. Critical to implant... Read More /publication/305339732_Biomechanical_Characterisation_of_the_Human_Auricular_Cartilages_Implications_for_Tissue_Engineering
Impact of storage conditions on electromechanical, histological and histochemical properties of osteochondral allograftsMickevicius T, Pockevicius A, Kucinskas A, Gudas R, Maciulaitis J, Noreikaite A and Usas ABMC Musculoskeletal Disorders, 16(1), 314. (2015)
Background: Osteochondral allograft transplantation has a good clinical outcome, however, there is still debate on optimization of allograft storage protocol. Storage temperature and nutrient medium composition are the most critical factors for... Read More Mickevicius-2015A
/publication/283263142_Impact_of_storage_conditions_on_electromechanical_histological_and_histochemical_properties_of_osteochondral_allografts
Electromechanical Assessment of Human Knee Articular Cartilage with Compression-Induced Streaming PotentialsBecher C, Ricklefs M, Willbold E, Hurschler C, and Abedian RCartilage, 7(1) 62-69. (2016)
To assess the electromechanical properties of human knee articular cartilage with compression-induced streaming potentials for reliability among users and correlation with macroscopic and histological evaluation tools and sulfated glycosaminoglycan (sGAG)... Read More Becher-2015.pdf
25th Anniversary Article: Engineering Hydrogels for BiofabricationMalda J, Visser J, Melchels FP, Jüngst T, Hennink WE, Dhert WJA, Groll J and Hutmacher DWAdv. Mater., 25: 5011–5028. doi:10.1002/adma.201302042 (2013)
With advances in tissue engineering, the possibility of regenerating injured tissue or failing organs has become a realistic prospect for the first time in medical history. Tissue engineering - the combination of bioactive materials with cells to generate... Read More /publication/256612829_25th_Anniversary_Article_Engineering_Hydrogels_for_Biofabrication
Tailoring hydrogel surface properties to modulate cellular response to shear loadingMeinert C, Schrobback K, Levett PA, Lutton C, Sah R and Klein TJActa biomaterialia, October 2016. DOI: 10.1016/j.actbio.2016.10.011
Biological tissues at articulating surfaces, such as articular cartilage, typically have remarkable low-friction properties that limit tissue shear during movement. However, these frictional properties change with trauma, aging, and disease, resulting... Read More /publication/309092382_Tailoring_hydrogel_surface_properties_to_modulate_cellular_response_to_shear_loading
A fibril-network-reinforced biphasic model of cartilage in unconfined compressionSoulhat J, Buschmann MD and Shirazi-Adl AJournal of Biomechanical Engineering, Jun, 121(3), 340-347. (1999)
Cartilage mechanical function relies on a composite structure of a collagen fibrillar network entrapping a proteoglycan matrix. Previous biphasic or poroelastic models of this tissue, which have approximated its composite structure using a homogeneous... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Effect of synovial fluid on boundary lubrication of articular cartilageSchmidt TA and Sah RLOsteoarthritis Cartilage. 2007 Jan;15(1):35-47. Epub 2006 Jul 21
OBJECTIVES: The lubrication of articulating cartilage surfaces in joints occurs through several distinct modes. In the boundary mode of lubrication, load is supported by surface-to-surface contact, a feature that makes this mode particularly... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Characterization of tissue engineered cartilage products - Recent developments in advanced therapyMaciulaitis J, Rekstyte S, Usas A, Jankauskaite V, Gudas R, Malinauskas M and Maciulaitis RPharmacological Research 113 (2016) 823–832
Legislative requirements for the quality of pharmacological agents underwent certain evolution when new type of therapies emerged. This relates to cell based medicines, such as tissue engineered cartilage products (TECP) which are increasingly developed... Read More /publication/310464880_Characterization_of_tissue_engineered_cartilage_products_Recent_developments_in_advanced_therapy_PR_16_JM
Review Paper: Fifty years of brain tissue mechanical testing: From in vitro to in vivo investigationsChatelin S, Constantinesco A and Willinger RBiorheology 47 (2010) 255–276. DOI 10.3233/BIR-2010-0576
Beginning in the 1960s many studies have been performed to investigate the mechanical properties of brain. In this paper we point out the difficulties linked with in vitro experimental protocols as well as the advantages of using recently developed non-invasive... Read More /publication/
Evaluation of genipin for stabilization of decellularized porcine cartilageElder S, Pinheiro A, Young C, Smith P and Wright EJ Orthop Res. 2016 Nov 18. doi: 10.1002/jor.23483
Abstract
We speculate that an acellular osteochondral xenograft may be a good alternative to allografts for repair of focal articular cartilage lesions. In order to make a xenograft resistant to enzymatic degradation and to prevent... Read More https://www.ncbi.nlm.nih.gov/pubmed/term=Evaluation+of+genipin+for+stabilization+of+decellularized+porcine+cartilage
Strengthening of C2C12 mouse myoblasts against compression damage by mild cyclic compressive stimulationYao Y and Mak AFJ Biomech. 2016 Dec 8;49(16):3956-3961. doi: 10.1016/j.jbiomech.2016.11.050. Epub 2016 Nov 16
Abstract Deep tissue injury (DTI) is a severe kind of pressure ulcers formed by sustained deformation of muscle tissues over bony prominences. As a major clinical issue, DTI affects people with physical disabilities, and is obviously... Read More https://www.ncbi.nlm.nih.gov/pubmed/
/publication/310657610_Strengthening_of_C2C12_mouse_myoblasts_against_compression_damage_by_mild_cyclic_compressive_stimulation
Improved cartilage integration and interfacial strength after enzymatic treatment in a cartilage transplantation modelvan de Breevaart Bravenboer J, In der Maur CD, Bos PK, Feenstra L, Verhaar JA, Weinans H, van Osch GJArthritis Res Ther. 2004;6(5):R469-76. Epub 2004 Aug 6
The objective of the present study was to investigate whether treatment of articular cartilage with hyaluronidase and collagenase enhances histological and mechanical integration of a cartilage graft into a defect. Discs of 3 mm diameter were taken from... Read More /publication/8334961_Improved_cartilage_integration_and_interfacial_strength_after_enzymatic_treatment_in_a_cartilage_transplantation_model
https://www.ncbi.nlm.nih.gov/pubmed/
Comparison of natural crosslinking agents for the stabilization of xenogenic articular cartilagePinheiro A, Cooley A, Liao J, Prabhu R and Elder SJ Orthop Res. 2016 Jun;34(6):1037-46. doi: 10.1002/jor.23121. Epub 2015 Dec 18.
Abstract Osteochondral xenografts are potentially inexpensive, widely available alternatives to fresh allografts. However, antigen removal from xenogenic cartilage may damage the extracellular matrix and reduce compressive stiffness.... Read More https://www.ncbi.nlm.nih.gov/pubmed/term=Comparison+of+natural+crosslinking+agents+for+the+stabilization+of+xenogenic+cartilage
Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile TestingGriffin M, Premakumar Y, Seifalian A, Butler PE and Szarko MJournal of Visualized Experiments: JoVE. 2016;(118):54872. doi:10.3791/54872.
Abstract
Regenerative medicine aims to engineer materials to replace or restore damaged or diseased organs. The mechanical properties of such materials should mimic the human tissues they are aiming to replace; to provide the required... Read More https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226394/
Study of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.Legrａnd C, Centonze P, Comblain F, Lambert C, Sanchez C and Henrotin YOsteoarthritis and Cartilage, 25, s314-s315.
Purpose: In animal models, the severity of cartilage damage is assessed Read More http://orbi.ulg.ac.be/bitstream/2268/209545/1/495.pdf
Injectable and degradable Poly(oligoethylene glycol methacrylate)-based hydrogels-synthetic versatility for improved biomaterial designBakaic E, Smeets N, Imbrogno S and Hoare TOral #327.3 on Friday, May 20 from 14:00 to 15:00 in room 524 during World Biomaterials Congress, Montreal, May 2016.
Introduction: Poly(ethylene glycol) (PEG)-based hydrogels are attractive biomaterials due to their hydrophilic, non-cytotoxic and non-immunogenic properties[1]. We recently reported on in situ-gelling PEG-analogue hydrogels based on poly(oligoethylene... Read More /10.3389/conf.FBIOE.2016.01.00728/event_abstractsname=10th_World_Biomaterials_Congress
Strain Rate Dependence in the Structure Property Relationship of Porcine BrainBegonia MG, Liao J, Horstemeyer MF and Williams LNPaper presented at the ASME 2009 Summer Bioengineering Conference. (2009)
This study examines the internal microstructure evolution of porcine brain during mechanical deformation. Strain rate dependency of porcine brain was investigated under quasi-static compression for strain rates of 0.00625, 0.025, and 0.10 s(-1). Confocal... Read More
Novel Biomechanical Indentation Test Demonstrates Joint Surface Weakening in Mice Lacking Fibroblast Growth Factor Receptor 3 (FGFR3)Binette JS, Laflamme F, Li W, Valverde-Franco G, Tran-Khanh N, Quenneville E, Henderson JE and Buschmann MDPaper presented at the 11th Canadian Connective Tissue Conference, Montreal, QC, Canada. (2005)
Recent advances in murine molecular genetics has enabled the production of mice with targeted disruption of genes that regulate cartilage and bone metabolism. These mice represent excellent models to study the 0 16 Wild Type etiology and progression of... Read More Binette-CCTC2005-poster.pdf
Mechanically tunable hydrogels for delivery of adipose derived stem cellsCarroll A, Anjum F, Young S, Flynn L and Amsden BGOral# 442.7 on Saturday, May 21 from 16:30 to 18:30 in room 524 during World Biomaterials Congress, Montreal, May 2016
Introduction: Chondroitin sulphate is an important component GAG found in articular cartilage and has a chondroinductive effect on adipose derived stem cells (ASCs). Methacrylate chondroitin sulphate (MCS) has therefore been chosen as a basis for... Read More /10.3389/conf.FBIOE.2016.01.02555/event_abstractsname=10th_World_Biomaterials_Congress
Highly oriented in situ gelling nanocomposite hydrogels as tissue engineering scaffolds for promoting directional cell growthDe France K, Yager KG, Chan KJ, Hoare TR and Cranston EDPoster #P.0554 on Thursday, May 19 from 15:00 to 16:30 in room 220BCD (P3) during World Biomaterials Congress, Montreal, May 2016
Introduction: Patterned hydrogels and polymer scaffolds have attracted attention as platforms for directed cell growth due to the significant impacts cell alignment has on tissue regeneration, mechanical properties and various other cell behaviours[1],[2].... Read More /10.3389/conf.FBIOE.2016.01.01953/event_abstractsname=10th_World_Biomaterials_Congress
Viscoelastic properties of collagen hydrogelsDrouin B, Lévesque L, Lainé A, Rosella E, Loy C and Mantovani DPoster #P.0890 on Thursday, May 19 from 15:00 to 16:30 in room 220BCD (P5) during World Biomaterials Congress, Montreal, May 2016
Introduction: Because of their exceptional biological properties, reconstituted collagen gels are widely used as scaffolds even though their low elastic modulus (~ 500 Pa) limits their applications[1],[2]. The mechanical properties of collagen... Read More /10.3389/conf.FBIOE.2016.01.00535/event_abstractsname=10th_World_Biomaterials_Congress
Fully injectable hydrazone-thiosuccinimide and hydrazone-disulfide interpenetrating polymer network hydrogels by kinetically orthogonal cross-linking of functionalized PNIPAM and PVP precurGilbert T and Hoare TPoster #P.0058 on Thursday, May 19 from 15:00 to 16:30 in room 220BCD (P1) during World Biomaterials Congress, Montreal, May 2016.
Introduction: IPNs are produced by interlocking two chemically distinct networks in each other’s free volume fraction. This interlocking and the potential for segregation of the IPNs into inhomogeneous domains can cause mechanical properties... Read More /10.3389/conf.FBIOE.2016.01.01047/event_abstractsname=10th_World_Biomaterials_Congress
Engineering degradable ''smart'' biomedical hydrogels on multiple length scalesHoare TOral #339.2 on Friday, May 20 from 16:30 to 18:30 in room 520B during World Biomaterials Congress, Montreal, May 2016
While multiple types of smart, environmentally-responsive materials have been explored for a variety of biomedical applications (e.g. drug delivery, tissue engineering, bioimaging, etc.), their ultimate clinical use has been hampered by their lack of... Read More /10.3389/conf.FBIOE.2016.01.00250/event_abstractsname=10th_World_Biomaterials_Congress
Articulation-Induced Responses of Superficial Zone Chondrocytes in Human Knee Articular Cartilage - Effects of Shear and SlidingHsu FH, Hui AY, Chen AC, Lotz MK and Sah ROrthopeadic Research Society Annual Meeting in Las Vegas, Abstract 0256
Introduction: During daily physical activities, joint articulation results in 3-10% compression in its overall thickness. There is also consensus that articulation is a combined process of shearing and sliding, with relative rotational and translational... Read More http://prgapps.com/AppUpdates/ors2015/Abstracts/abs256.html
Poro-viscoelastic models applied to porous gelatin scaffoldsLainé A, Drouin B and Mantovani DPoster #P.0901 on Wed May 18 from 15:00 to 16:30 in room 220BCD (P5) during World Biomaterials Congress, Montreal, May 2016.
Introduction: Scaffolds are among the key components of a tissue-engineered construct. Although many different proteins have been used in scaffold preparation, gelatin, which is obtained by degradation of collagen, is a completely biodegradable,... Read More /10.3389/conf.FBIOE.2016.01.02699/event_abstractsname=10th_World_Biomaterials_Congress
The effects of frequency on matrix remodeling induced in dynamically strained collagen-based cellularised scaffoldsLevesque L, Loy C, Lainé A, Bono N, Drouin B and Mantovani DOral.238.51 on Wed May 19 from 16:30 to 18:30 in room 519 during World Biomaterials Congress, Montreal, May 2016
Introduction: In vascular tissue engineering, the understanding of cells behavior inside matrices and under pseudo-physiological treatment is of upmost importance in order to develop arteries and arterial wall models. Indeed, extracted collagen... Read More /10.3389/conf.FBIOE.2016.01.00309/event_abstractsname=10th_World_Biomaterials_Congress
Cellularized collagen gels for tissue engineered vascular wall: in vitro models alternative to in vivo testingLoy C, Meghezi S, Seifu DG, Pezzoli D , Bono N , Levesque L, Drouin B and Mantovani DPoster #P.0616 on Thursday May 19 from 15:00 to 16:30 in room 220BCD (P3) during World Biomaterials Congress, Montreal, May 2016.
Introduction: Type I collagen-gels, as scaffolds for vascular tissue engineering, have a high potential for supporting and guiding vascular cells in the regeneration process. With this in mind, our project was to develop a set of easy-to-prepare... Read More /10.3389/conf.FBIOE.2016.01.00135/event_abstractsname=10th_World_Biomaterials_Congress
Changes in Collagen and Sulphated Proteoglycan Synthesis by Multilamellated AF Tissues Cultured in vitro on Aligned Nanofibrous Polyurethane Constructs Under Dynamic Compressive LoadingIu J, Santerre JP and Kandel RAPresentation #331.2 on Fri May 20 from 16:30 to 18:30 in room 511E during the World Congress on Biomechanics, Montreal, May 2016.
Introduction: Current treatments for chronic neck or low back pain are not optimal. The replacement of a degenerated intervertebral disc (IVD) with a bioengineered IVD has been investigated as a potential alternative approach. The IVD is composed... Read More /10.3389/conf.FBIOE.2016.01.03015/event_abstractsname=10th_World_Biomaterials_Congress
Dynamic Axial Loading Disrupts Lateral Integration of Arthritic Human Articular Cartilage and Synthetic Tissue Engineered Scaffolds in an Ex Vivo Ring ModelMintz BR, Papaliodis D, Jordan S, Leonard G, Mulligan M and Cooper JAOrthopeadic Research Society Annual Meeting in Las Vegas, 2015, Abstract 0390
Introduction: Common surgical procedures including mosaicplasty, microfracture, and autologous chondrocyte implantation to promote articular cartilage regeneration account for ~40% of knee arthroscopy.[1] These procedures are reliant on proper... Read More http://prgapps.com/AppUpdates/ors2015/Abstracts/abs390.html
Contrast-Enhanced Computed Tomography Reflects Stiffness of Intact Articular CartilageNickmanesh R, Stewart R, Snyder B, Grinstaff M and Wilson DISMRM Workshop on Imaging Based Measures of Osteoarthritis. Sept 11-14, 2015. Pacific Grove, CA, USA. Presentation on Sept 13 at 14:39.
Purpose: Articular cartilage distributes load in joints and provides a low-friction surface for joint movement. Glycosaminoglycan (GAG) in cartilage plays a critical role in its compressive stiffness. Loss of GAG is an early sign of osteoarthritis... Read More Nickmanesh-IWOAI2015-abstract.pdf
The Effect Of Superimposed Vibrations On Chondrocytes Subjected To Dynamic Compressive LoadingWeber J and Waldman SOrthopeadic Research Society Annual Meeting in Las Vegas, Abstract 1244
Introduction: Mechanical stimulation is often used as a means to accelerate and improve the growth and properties of tissue engineered cartilage constructs. However, as cartilage cells (chondrocytes) rapidly desensitize to the imposed stimulus... Read More http://prgapps.com/AppUpdates/ors2015/Abstracts/abs1244.html
Direct reactive electrospinning of degradable hydrogel nanofibers for tissue engineeringXu F, Gough I and Hoare TOral #520.5 on Sunday, May 22 from 14:00 to 16:00 in room 516C during World Biomaterials Congress, Montreal, May 2016.
Hydrogels have received considerable attention in the context of soft tissue engineering due to their as high water contents, (general) cell compatibility, and physicochemical and mechanical similarities to native soft tissues[1]. Most hydrogels used... Read More /10.3389/conf.FBIOE.2016.01.01238/event_abstractsname=10th_World_Biomaterials_Congress
Electroarthrography, a non-invasive streaming potential-based method, measures cartilage quality in live horsesChangoor A, Brett W, Hoba MA, Garon M, Quenneville E, Gordon K, Savard P, Buschmann MD, Hurtig MB and Trout DROsteoarthritis and Cartilage, Vol. 22, Supplement 1, 138, World Congress on Osteoarthritis, April 2014, Paris, France.
Introduction: Degenerative joint diseases, including osteoarthritis, are characterized by progressive cartilage degeneration, which can lead to pain and loss of joint function. Therapeutics administered early, when only low grade cartilage changes... Read More Changoor-OARSI2014-Poster.pdf
Non-invasive Electroarthrography Correlates to Direct Measurements of Cartilage Streaming Potentials in Weight Bearing Regions of Equine Metacarpophalangeal (Fetlock) JointsChangoor A, Hoba MA, Garon M, Quenneville E, Gordon K, Savard P, Buschmann MD and Hurtig MBTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA, 1123 (2014)
Introduction/Purpose: Electroarthrography (EAG) is a new technology that non-invasively measures cartilage streaming potentials through electrodes contacting the skin surrounding an articular joint. Streaming potentials are produced during cartilage... Read More Changoor-ORS2014.pdf
Freeze-dried chitosan-PRP implants improve meniscus repair in an ovine modelGhazi Zadeh L, Chevrier A, Hurtig M, Farr J, Rodeo S, Hoemann C and Buschmann MInternational Cartilage Repair Society (ICRS), Sorrento, 2016, Poster P112
Purpose: Menisci are structurally complex and play an essential weight-bearing role in the knee joint. Although there has been a recent increase in the number of meniscus repairs performed yearly in the US [1], only a small number of all meniscal... Read More Zadeh-2016A ICRS2016 Poster
/icrs2016/confcal/ghazi
Streaming Potential-Based Arthroscopic Device Discerns Topographical Differences In Cartilage Covered And Uncovered By Meniscus In Ovine Stifle JointsChangoor A, Quenneville E, Garon M, Cloutier L, Hurtig MB and Buschmann MDTransactions of the 53th Annual Meeting of the Orthopaedic Research Society, San Diego, CA, USA, 32:631. (2007)
Animal models of osteoarthritis have been used for understanding diseaseprogression and are essential for assessing potential new therapies. Ovine models, such as the lateral meniscectomy model, are of interest because meniscectomy models often follow... Read More Changoor-ORS2007-poster.pdf
Electroarthrography Provides a Non-invasive Streaming Potential-Based Method for Detecting Cartilage Degeneration in an Equine Model TransactionsChangoor A, Hoba MA, Quenneville E, Garon M, Gordon K, Buschmann MD, Savard P and Hurtig MBThe 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX, USA, 1974. (2013)
Degenerative joint diseases, like osteoarthritis, are characterized by progressive cartilage degeneration, which can lead to pain and loss of mobility. Low-grade cartilage deterioration occurs early in disease progression and may be treatable. However,... Read More Changoor-2013-Poster.pdf
Assessment of allograft performance in vivo using electromechanical properties of articular cartilageUsas A, Mickevicius T, Pockevicius A, Kucinskas A, Maciulaitis J and Gudas RInternational Cartilage Repair Society (ICRS), Sorrento, 2016, Poster P211
Purpose: Clinical outcome of osteochondral allograft transplantation (OAT) depends on allograft quality. There is a lack of rapid and reliable non-destructive methods for intraoperative evaluation of repaired cartilage. Measurement of cartilage... Read More /icrs2016/confcal/usas
Biomechanical characterisation of the human nasal cartilages - implications for tissue engineeringGriffin MF, Premakumar Y, Seifalian AM, Szarko M and Butler PEMJournal of Materials Science: Materials in Medicine, 27(1), 1-6. (2016)
Nasal reconstruction is currently performed using autologous grafts provides but is limited by donor site morbidity, tissue availability and potentially graft failure. Additionally, current alternative alloplastic materials are limited by their high extrusion... Read More
Mechanical characterization of matrix-induced autologous chondrocyte implantation (MACI®) grafts in an equine model at 53 weeksGriffin DJ, Bonnevie ED, Lachowsky DJ, Hart JC, Sparks HD, Moran N and Bonassar LJJournal of biomechanics, 48(10), 1944-1949. (2015)
There has been much interest in using autologous chondrocytes in combination with scaffold materials to aid in cartilage repair. In the present study, a total of 27 animals were used to compare the performance of matrix-assisted chondrocyte implantation... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Decrease of the electrical potentials measured on the surface of the knee and produced by cartilage compression during successive loading cyclesZhu L, Garon M, Quenneville E, Buschmann MD and Savard PJournal of Biomechanics, 49(14), 3587-3591. (2016)
Electroarthrography (EAG) is a new technique formeasuring electrical potentials appearing on the knee surface during loadingthat reflects cartilage quality and joint contact force. Our objective was toinvestigate the evolution of EAG signals during successive... Read More https://www.ncbi.nlm.nih.gov/pubmed/
/publication/308352591_Decrease_of_the_electrical_potentials_measured_on_the_surface_of_the_knee_and_produced_by_cartilage_compression_during_successive_loading_cycles
Mechanical loading of knee articular cartilage induced by muscle contraction can be assessed by measuring electrical potentials at the surface of the kneeZhu L, Buschmann MD and Savard PJournal of biomechanics, 49(3), 338-343. (2016)
Electroarthrography (EAG) consists of recording electrical potentials on the knee surface that originate from streaming potentials within articular cartilage while the joint is undergoing compressive loading. The aim was to investigate how the contraction... Read More /publication/288919310_Mechanical_loading_of_knee_articular_cartilage_induced_by_muscle_contraction_can_be_assessed_by_measuring_electrical_potentials_at_the_surface_of_the_knee
Change in viability of C2C12 myoblasts under compression, shear and oxidative challengesHong Y, Yao Y, Wong S, Bian L and Mak AFJournal of biomechanics, 49(8), 1305-1310. (2016)
Skeletal and epidermal loadings can damage muscle cells and contribute to the development of deep tissue injury (DTI) – a severe kind of pressure ulcers affecting many people with disability. Important predisposing factors include the multiaxial stress... Read More https://www.ncbi.nlm.nih.gov/pubmed/
/publication/270596382_The_Effects_of_Oxidative_Stress_on_the_Compressive_Damage_Thresholds_of_C2C12_Mouse_Myoblasts_Implications_for_Deep_Tissue_Injury
/publication/270596382_The_Effects_of_Oxidative_Stress_on_the_Compressive_Damage_Thresholds_of_C2C12_Mouse_Myoblasts_Implications_for_Deep_Tissue_Injury/figures
Biomechanics and MechanoBiology of Human Cartilage ArticulationHsu FH, Alonso E, Raleigh AR, Saleh AA, Masuda K, Lotz MK, Chen AC and Sah ROrthopeadic Research Society Annual Meeting, 2016, Orlando, USA, Poster abstract 1428
Introduction: During joint articulation, cartilage, particularly that near the articular surface, undergoes a complex combination of compression, shear, and sliding.1,2 In vitro analyses have focused on cartilage biomechanics in response to... Read More /Transactions/62/1428.pdf
Effects of Biowastes Released by Mechanically Damaged Muscle Cells on the Propagation of Deep Tissue Injury: A Multiphysics StudyYao Y, Da Ong LX, Li X, Wan K and Mak AFAnnals of Biomedical Engineering March 2017, Volume 45, Issue 3, pp 761–774
Deep tissue injuries occur in muscle tissues around bony prominences under mechanical loading leading to severe pressure ulcers. Tissue compression can potentially compromise lymphatic...
Read More
Changes in growth plate extracellular matrix composition and biomechanics following in vitro static versus dynamic mechanical modulationKaviani R, Londono I, Parent S, Moldovan F and Villemure IJ Musculoskelet Neuronal Interact, 1-11 (2017)
The objective of this study was to investigate the effects of mechanical modulation parameters on structural proteins biocomposition and mechanical properties of the growth plate. Establishing these parameters is a crucial step in the development... Read More /jmni/accepted/jmni_aa_KAVIANI.pdf
Autonomously Self-Adhesive Hydrogels as Building Blocks for Additive ManufacturingDeng X, Attalla R, Sadowski LP, Chen M, Majcher MJ, Urosev I, Yin D-C, Selvaganapathy PR, Filipe CDM and Hoare TBiomacromolecules 2017, Published Online, doi: 10.1021/acs.biomac.7b01243
We report a simple method of preparing autonomous and rapid self-adhesive hydrogels and their use as building blocks for additive manufacturing of functional tissue scaffolds. Dynamic crosslinking between 2-aminophenylboronic acid-functionalized hyaluronic... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Ermittlung mechanischer Kennwerte mittels IndentationSeidenstucker MBioNanoMat. 2015; 16 (2-3): 152–156 DOI 10.1515/bnm-2015-9014
(In Germany only) In der Materialprüfung sind Indentationsverfahren bereits seit Jahren gngige Praxis. Jedoch war es bisher nicht so ohne weiteres mglich Gewebeproben, insbesondere Weichgewebe wie Knorpel zu untersuchen. Mit dem Mikroindenter Mach-1TM... Read More Seidenstucker-2015-presentation.pdf
Seidenstucker-2015.pdf
Guidelines for an optimized indentation protocol for measurement of cartilage stiffness - The effects of spatial variation and indentation parametersMoshtagh PR, Pouran B, Korthagen NM, Zadpoor AA and Weinans HJournal of Biomechanics 49(14) · September 2016 DOI: 10.1016/j.jbiomech.2016.09.020
Mechanical properties of articular cartilage that are vital to its function are often determined by indentation tests, which can be performed at different scales. Cartilage tissue exhibits various types of structural, geometrical, and spatial variations... Read More https://www.ncbi.nlm.nih.gov/pubmed/
/publication/308351970_Guidelines_for_an_optimized_indentation_protocol_for_measurement_of_cartilage_stiffness_The_effects_of_spatial_variation_and_indentation_parameters
Tough, Semisynthetic Hydrogels for Adipose Derived Stem Cell Delivery for Chondral Defect RepairAnjum F, Carroll A, Young SA, Flynn LE and Amsden BGMacromol Biosci. 2017 Jan 13. doi: 10.1002/mabi.201600373.
Cell-based therapies have great potential to regenerate and repair injured articular cartilage, and a range of synthetic and natural polymer-based hydrogels have been used in combination with stem cells and growth factors for this purpose. Although the... Read More https://www.ncbi.nlm.nih.gov/pubmed/
Cryogenic 3D Printing of Super Soft HydrogelsForte AE, Parisi C, Dini D, Di Silvio L and Tan ZScientific Reports 7, Article number: 16293 (2017) doi:10.1038/s41598-017-16668-9
Conventional 3D bioprinting allows fabrication of 3D scaffolds for biomedical applications. In this contribution we present a cryogenic 3D printing method able to produce stable 3D structures by utilising the liquid to solid phase change of a composite... Read More /articles/s41598-017-16668-9WT.feed_name=subjects_scientific-community-and-society
Effect of Multiple Confined Compression/Stress Relaxation Cycles on Cross-linked Alginate Pore SizeKolar Venkat S, Risa EL, Antell B and Mobed-Miremadi MBiomedical Engineering Society 2017 (BMES) Phoenix - Arizona
Introduction: Alginate is a biopolymer and hydrogel comprised of (1,4)-linked -D-mannuronic (M) and (1,3)-- L-guluronic (G) acid residues. The average pore size associated with crosslinked high MW 1-2 (w/v%) alginate structures has been reported... Read More http://scholarsarchive.byu.edu/cgi/viewcontent.cgiarticle=1061&context=bmes
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