修飾性PEG的用途介紹：
1、 蛋白質(zhì)類藥物PEG修飾： PEG修飾蛋白質(zhì)藥物可以延長藥物的半衰期、降低免疫原性，同時zui大限度地保留其生物活性。作為治療藥物，經(jīng)過聚乙二醇(PEG)修飾的蛋白質(zhì)比未修飾的蛋白質(zhì)更有效。PEG對蛋白藥物修飾途徑主要有氨基修飾（包括N端氨基的酰化修飾、賴氨酸側(cè)鏈氨基的?；揎?、N端氨基的烷基化修飾）、羧基修飾、巰基修飾等。目前，國內(nèi)外對PEG修飾蛋白質(zhì)類藥物的研究主要集中于腺苷脫氨酶、天冬酰胺酶、干擾素、粒細胞集落刺激因子、白細胞介素等，更有40多個藥物正在進行臨床研究。
2、 肽類化合物PEG修飾：肽類化合物PEG修飾，如畦降鈣素、表皮生長因子的PEG修飾產(chǎn)物的半衰期和生物活性顯著高于原型藥物。尤其是肽類化合物在聚乙二醇定點修飾方面較蛋白質(zhì)更易于實現(xiàn)。在肽類化合物的PEG修飾研究中應(yīng)用zui普遍的是mPEG。
3、PEG修飾脂質(zhì)體：普通免疫脂質(zhì)體由于在血液中的循環(huán)半衰期短，易于被清除，限制了其發(fā)展。PEG修飾的長循環(huán)脂質(zhì)體，增加了脂質(zhì)體的血液循環(huán)時間，不但能夠逃避網(wǎng)狀內(nèi)皮系統(tǒng)的捕獲，還能提高脂質(zhì)體的被動靶向性。已經(jīng)被廣泛用于脂質(zhì)體藥物制劑。
4、PEG修飾有機小分子藥物：很多小分子藥物，目前以抗腫瘤藥物為多，采用PEG修飾技術(shù)，聚乙二醇支載小分子，可以把它的許多優(yōu)良性質(zhì)也隨之轉(zhuǎn)移到結(jié)合物中，使該聚合物具有優(yōu)異的生物相容性，在體內(nèi)能溶于組織液中，能被機體迅速排出體外而不產(chǎn)生任何毒副作用。很多抗腫瘤藥物通過高分子量PEG修飾，能夠達到腫瘤組織的被動靶向給藥。
5、其它他應(yīng)用：PEG修飾親和配體和輔因子在含水的兩相分配系統(tǒng)中應(yīng)用，用于生物大分子和細胞的純化和分析。PEG修飾糖類可作為新的藥物材料、藥物載體。寡核苷酸PEG化可以增加溶解度，增加對核酸酶的抵抗和細胞膜穿透性。生物材料PEG化可以減少血栓形成，降低蛋白質(zhì)和細胞黏附性。
供應(yīng)商：西安凱新生物科技有限公司
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氨基產(chǎn)品目錄表：
mPEG-NHS, MW:2000
mPEG-CHO, MW:350
mPEG-NPC, MW:550
mPEG-PFP, MW:1000
mPEG-S-S-NHS, MW:3400
mPEG-SPA, MW:5000
mPEG-SVA, MW:750
NHS-PEG-NHS, MW:10000
NHS-PEG-MAL, MW:5000
NHS-PEG-Biotin, MW:2000
NHS-PEG-FITC, MW:5000
NHS-PEG-Silane, MW:20000
Diethoxylsilane-PEG-NHS, MW:5000
Monoethoxylsilane-PEG-NHS, MW:5000
NHS-PEG-DSPE, MW:2000
NHS-PEG-CLS, MW:1000
NHS-PEG-COOH, MW:3400
NHS-PEG-OH
CHO-PEG-CHO, MW:550
NPC-PEG-NPC, MW:1000
mPEG-EPO, MW:20000
EPO-PEG-EPO, MW:1000
mPEG-ISC, MW:40000
mPEG-ITC. MW:2000
ISC-PEG-ISC, MW:3400
mPEG-Tosylate, MW:5000
巰基產(chǎn)品目錄表：
Maleimide PEG, mPEG-MAL, MW:2000
Maleimide PEG Maleimide, MAL-PEG-MAL, MW:1000
Maleimide PEG NHS, MAL-PEG-NHS, MW:750
Maleimide PEG PFP, MAL-PEG-PFP, MW:3400
Maleimide PEG Biotin, MAL-PEG-Biotin, MW:5000
Maleimide PEG Fluorescein, MAL-PEG-FITC, MW:1000
Maleimide PEG Silane, MAL-PEG-Silane, MW:3400
Maleimide PEG Amine, MAL-PEG-NH2, MW:2000
Maleimide PEG Acid, MAL-PEG-COOH, MW:10000
Ortho-pyridine disulfide PEG, mPEG-OPSS, MW:750
OPSS-PEG-OPSS, MW:1000
OPSS-PEG-NHS, MW:2000
OPSS-PEG-Biotin, MW:2000
OPSS-PEG-NH2, MW:3400
OPSS-PEG-COOH, MW:550
Iodoacetyl PEG, mPEG-IA, MW:20000
Iodoacetyl PEG NHS, IA-PEG-NHS, MW:5000
Iodoacetyl PEG Maleimide, IA-PEG-MAL, MW:2000
Iodoacetyl PEG amine, IA-PEG-NH2, MW:3400
Iodoacetyl PEG Biotin, IA-PEG-Biotin, MW:1000
Iodoacetyl PEG Acid, IA-PEG-COOH, MW:5000
PEG di-iodoacetate, IA-PEG-IA, MW:3400
Vinylsulfone PEG, mPEG-VS, MW:2000
Vinylsulfone PEG acid, VS-PEG-COOH, MW:1000
Vinylsulfone PEG Fluorescein, VS-PEG-FITC, MW:5000
Vinylsulfone PEG Biotin, VS-PEG-Biotin, MW:20000
Vinylsulfone PEG DSPE, VS-PEG-DSPE, MW:550
Vinylsulfone PEG Silane, VS-PEG-Silane, MW:3400
Monofunctional PEGs產(chǎn)品目錄表：
Methoxyl PEG, mPEG-OH
Amino PEG, Methoxy PEG Amine, mPEG-NH2
Carboxylic PEG acid, mPEG-COOH
Thiol PEG, methoxy PEG Thiol, mPEG-SH
Azido PEG, mPEG-N3
Hydrazide PEG, mPEG-HAZ
Acrylate PEG, mPEG-ACR
Succinimidyl PEG NHS, mPEG-NHS(SC)
Succinimidyl propionic acid PEG NHS, mPEG-SPA
Succinimidyl valeric acid PEG NHS, mPEG-SVA
Methoxyl PEG Aldehyde, mPEG-CH2CHO
PEG Nitrophenyl Carbonate PEG, mPEG-NPC
Epoxide PEG, mPEG-EPO
Isocyanate PEG, mPEG-ISC
Isothiocyanate PEG, mPEG-ITC
Maleimide PEG, mPEG-MAL
Ortho-pyridine disulfide PEG, mPEG-OPSS
Iodoacetyl PEG, mPEG-IA
Vinylsulfone PEG, mPEG-VS
PEG Biotin, mPEG-Biotin
Fluorescein PEG, mPEG-FITC
Rhodamine-PEG, mPEG-RB
Silane PEG, mPEG-Silane
Lipoic acid PEG, mPEG-LA
DSPE PEG, mPEG-DSPE
DMPE PEG, mPEG-DMPE
DPPE PEG, mPEG-DPPE
DLPE PEG, mPEG-DLPE
Cholesterol PEG, mPEG-CLS
DBCO PEG, mPEG-DBCO
Homobifunctional PEG
產(chǎn)品目錄：
HO-PEG-OH
Amino PEG Amine, NH2-PEG-NH2
Thiol PEG Thiol, HS-PEG-HS
Carboxylic Acid PEG Acid, HOOC-PEG-COOH
Hydrazide-PEG-Hydrazide
Aldehyde PEG Aldehyde, CHO-PEG-CHO
Bifunctional NHS PEG, NHS-PEG-NHS
Bifunctional NPC PEG, NPC-PEG-NPC
Epoxide PEG Epoxide, EPO-PEG-EPO
Isocyanate PEG Isocyanate, ISC-PEG-ISC
Maleimide PEG Maleimide, MAL-PEG-MAL
OPSS-PEG-OPSS
PEG di-iodoacetate, IA-PEG-IA
Biotin-PEG-Biotin
PEG di-vinylsulfone, VS-PEG-VS
PEG di-acrylate, Acrylate-PEG-Acrylate
CDI-PEG-CDI
PFP-PEG-PFP, pentafluorophenyl PEG
Heterobifunctional PEG產(chǎn)品目錄：
Amino PEG Acid, NH2-PEG-COOH
Amino PEG hydroxyl, NH2-PEG-OH
Maleimide PEG NHS, MAL-PEG-NHS
Maleimide PEG PFP, MAL-PEG-PFP
Maleimide PEG Amine, MAL-PEG-NH2
Maleimide PEG Acid, MAL-PEG-COOH
NHS-PEG-COOH
NHS-PEG-OH
Biotin-PEG-NHS
Biotin-PEG-NH2
Biotin-PEG-COOH
Biotin-PEG-Maleimide
Biotin-PEG-FITC
Biotin PEG Thiol, Biotin-PEG-SH
Thiol PEG Amine, HS-PEG-NH2
Thiol PEG Acid, HS-PEG-COOH
Thiol PEG OH, HS-PEG-OH
Thiol PEG Azide, HS-PEG-N3
Thiol PEG Fluorescein, HS-PEG-FITC
DSPE-PEG-NHS
DSPE-PEG-Maleimide, DSPE-PEG-MAL
DSPE PEG Biotin
DSPE PEG Amine, DSPE-PEG-NH2
DSPE PEG Acid, DSPE-PEG-COOH
Silane-PEG-Amine
Silane-PEG-COOH
Silane-PEG-Biotin
Silane-PEG-Maleimide
Silane-PEG-NHS
Silane-PEG-SH
Azido PEG hydroxyl, N3-PEG-OH
Azido PEG amine, N3-PEG-NH2
Azido PEG acid, N3-PEG-COOH
Azido PEG NHS, N3-PEG-NHS
Azido PEG Maleimide, N3-PEG-Mal
Azido PEG Biotin, N3-PEG-Biotin
Fluorescein PEG NHS, FITC-PEG-NHS
Fluorescein PEG Amine, FITC-PEG-NH2
Fluorescein PEG Maleimide, FITC-PEG-Mal
Fmoc-NH-PEG-NHS
Fmoc-NH-PEG-NH2
Fmoc-NH-PEG-COOH
Boc-NH-PEG-NHS
Boc-NH-PEG-NH2
Boc-NH-PEG-COOH
Acryloyl PEG COOH
Acryloyl PEG NHS
Acryloyl PEG NH2
Alkyne PEG amine, Alkyne-PEG-NH2
Alkyne PEG acid, Alkyne-PEG-COOH
Alkyne PEG thiol, Alkyne-PEG-SH
Alkyne PEG NHS, Alkyne-PEG-NHS
Alkyne PEG Maleimide, Alkyne-PEG-Mal
Alkyne PEG Biotin, Alkyne-PEG-Biotin
Biotinylated PEGs
Nanocs provides a variety of biotin PEG derivatives that include Biotin PEG NHS, biotin PEG maleimide, fluorescent PEG biotins, lipid PEG biotins and many other biotinylated,
multifunctional PEG reagents.
產(chǎn)品列表：
PEG Biotin, mPEG-Biotin
Biotin-PEG-NHS
Biotin-PEG-PFP
Biotin-PEG-NH2
Biotin PEG hydrazide
Biotin-PEG-COOH
Biotin-PEG-OH
Biotin-PEG-Maleimide
Biotin-PEG-FITC
Biotin-PEG-Biotin
Biotin-PEG-SH
Other Fluorescent PEG Biotin
Folic Acid PEG Biotin
Desthiobiotin-PEG-X
Iminobiotin-PEG-X
產(chǎn)品列表Surface Reactive PEGs：
Silane PEG, mPEG-Silane
Silane-PEG-Amine
Silane-PEG-COOH
Silane-PEG-Biotin
Silane-PEG-Maleimide
Silane-PEG-NHS
Silane-PEG-SH
Silane-PEG-OPSS
Silane-PEG-FITC
Silane-PEG-Acrylate
Silane-PEG-N3, Silane PEG Azide
Thiol PEG, methoxy PEG Thiol, mPEG-SH
Thiol PEG Amine, HS-PEG-NH2
Thiol PEG Acid, HS-PEG-COOH
Thiol PEG NHS, HS-PEG-NHS
Thiol PEG OH, HS-PEG-OH
Thiol PEG Biotin, HS-PEG-Biotin
Thiol PEG Azide, HS-PEG-N3
Thiol PEG Alkyne, HS-PEG-Alk
Thiol PEG Fluorescein, HS-PEG-FITC
Lipoic acid PEG, mPEG-LA
Lipoic acid PEG amine, LA-PEG-NH2
Lipoic acid PEG acid, LA-PEG-COOH
Lipoic acid PEG NHS, LA-PEG-NHS
Lipoic acid PEG, LA-PEG-Biotin
Lipoic acid PEG, LA-PEG-OH
Lipoic acid PEG, LA-PEG-FITC
Lipoic acid PEG, LA-PEG-NHS
Lipoic acid PEG, LA-PEG-MAL
Fluorescent PEGs產(chǎn)品目錄表：
Fluorescein PEG, mPEG-FITC
Fluorescein PEG Amine, FITC-PEG-NH2
Fluorescein PEG hydroxyl, FITC-PEG-OH
Fluorescein PEG acid, FITC-PEG-COOH
Fluorescein PEG Thiol, FITC-PEG-SH
Fluorescein PEG Biotin, FITC-PEG-Biotin
Fluorescein PEG NHS, FITC-PEG-NHS
Fluorescein PEG Azide, FITC-PEG-N3
Fluorescein PEG Maleimide, FITC-PEG-Mal
Rhodamine-PEG, mPEG-RB
Rhodamine PEG hydroxyl, RB-PEG-OH
Rhodamine PEG Amine, RB-PEG-NH2
Rhodamine PEG Thiol, RB-PEG-SH
Rhodamine PEG Acid, RB-PEG-COOH
Rhodamine PEG Biotin, RB-PEG-Biotin
Rhodamine-PEG-NHS,RB-PEG-NHS
Rhodamine-PEG-MAL,RB-PEG-MAL
Cy5 PEG Amine, Cy5-PEG-NH2
Cy5 PEG NHS, Cy5-PEG-NHS
Cy5 PEG acid, Cy5-PEG-COOH
Cy5 PEG Maleimide, Cy5-PEG-Mal
Cy5 PEG Thiol, Cy5-PEG-SH
Cy5 PEG Biotin, CY5-PEG-Biotin
Cy5 PEG Folic acid, Cy5-PEG-FA
Cy3 PEG Amine, Cy3-PEG-NH2
Cy3 PEG NHS, Cy3-PEG-NHS
Cy3 PEG acid, Cy3-PEG-COOH
Cy3 PEG Maleimide, Cy3-PEG-Mal
Cy3 PEG Thiol, Cy3-PEG-SH
Cy3 PEG Biotin, Cy3-PEG-Biotin
Cy3 PEG Folic acid, Cy3-PEG-fa
Other Cy3 PEG Derivatives
Click PEG Derivatives產(chǎn)品目錄表：
mPEG-DBCO
DBCO PEG NHS, DBCO-PEG-NHS
DBCO PEG Maleimide, DBCO-PEG-MAL
DBCO PEG Amine, DBCO-PEG-NH2
DBCO PEG acid, DBCO-PEG-COOH
DBCO PEG DSPE
DBCO PEG Silane
DBCO PEG Biotin
DBCO PEG Flurorescein, DBCO-EPG-FITC
DBCO PEG Cy3
DBCO PEG Cy5
Polymerizable PEGs產(chǎn)品目錄表：
Acrylate PEG, mPEG-ACR
Methacrylate PEG, mPEG-MACR
Acrylate PEG NHS
Acrylate PEG Maleimide
Acrylate PEG Biotin
Acrylate PEG Amine, Acrylate-PEG-NH2
Acrylate PEG Acid, Acrylate-PEG-COOH
Acrylate PEG Acrylate
Multiarm PEGs產(chǎn)品目錄表：
2 Arm/Branched PEG Acid 10000 Da
2 Arm/Branched PEG Acid 4000 Da
2 Arm/Branched PEG Amine 10000 Da
2 Arm/Branched PEG Amine 4000 Da
2 Arm/Branched PEG NHS 10000 Da
2 Arm/Branched PEG NHS 4000 Da
2 Arm/Branched PEG Maleimide 10000 Da
2 Arm/Branched PEG Maleimide 4000 Da
2 Arm/Branched PEG Biotin 10000 Da
2 Arm/Branched PEG Biotin
4-Arm PEG Acrylate
4-Arm PEG Amine
4-Arm PEG Thiol
4-Arm PEG Maleimide
4-Arm PEG NHS
4-Arm PEG Biotin
4 Arm PEG vinyl sulfone
8-Arm PEG Amine
8-Arm PEG Thiol
8-Arm PEG NHS
8-Arm PEG Maleimide
8-Arm PEG Biotin
8 Arm PEG vinyl sulfone
Other PEG Reagents產(chǎn)品目錄表：
Folic Acid PEG, mPEG-FA Folic
Acid PEG Amine, FA-PEG-NH2
Folic Acid PEG Acid, FA-PEG-COOH
Folic Acid PEG Thiol, FA-PEG-SH
Folic Acid PEG DSPE
Folic Acid PEG NHS
Folic Acid PEG Maleimide
Folic Acid PEG Biotin
Folic Acid PEG FITC
Vitamin E PEG, mPEG alfa-tocopherol
Vitamin E PEG, mPEG alfa-tocopherol
Vitamin E PEG, mPEG alfa-tocopherol
Vitamin E PEG NHS, Tocopherol PEG NHS
Vitamin E PEG NHS, Tocopherol PEG NHS
Vitamin E PEG NHS, Tocopherol PEG NHS
Vitamin E PEG NH2, Tocopherol PEG amine
Vitamin E PEG NH2, Tocopherol PEG amine
Vitamin E PEG NH2, Tocopherol PEG amine
Vitamin E PEG Maleimide, Tocopherol PEG maleimide
Vitamin E PEG Maleimide, Tocopherol PEG maleimide
Vitamin E PEG Maleimide, Tocopherol PEG maleimide
Vitamin D PEG, mPEG Vitamin D
Vitamin D PEG, mPEG Vitamin D
Vitamin D PEG, mPEG Vitamin D
Vitamin D PEG, mPEG Vitamin D
Vitamin D PEG, mPEG Vitamin D
Vitamin D PEG NHS
Vitamin D PEG NHS
Vitamin D PEG NHS
Vitamin D PEG NH2
Vitamin D PEG NH2
Vitamin D PEG NH2
Vitamin D PEG Maleimide
Vitamin D PEG Maleimide
Vitamin D PEG Maleimide
Vitamin A/Retinoic acid PEG, mPEG Retinoic acid
Vitamin A/Retinoic acid PEG, mPEG Retinoic acid
Vitamin A/Retinoic acid PEG, mPEG Retinoic acid
Retinoic acid PEG NHS
Retinoic acid PEG Biotin
Retinoic acid PEG FITC
PEG amino acid/peptide Conjugates
產(chǎn)品列表：
mPEG L-Lysine
mPEG L-Lysine
Lysine PEG Lysine
4 Arm PEG L-Lysine
8 Arm PEG L-Lysine
mPEG Cysteine
Cysteine PEG Cysteine
4 Arm PEG Cysteine
mPEG Glutathione
Glutathione PEG Glutathione
4 Arm PEG Glutathione
mPEG Aspartic Acid
Aspartic Acid PEG Aspartic Acid
4 Arm PEG Aspartic Acid
mPEG Glutamic Acid
Glutamic Acid PEG Glutamic Acid
4 Arm PEG Glutamic Acid
PEG Metal Chelate Conjugates
mPEG DTPA
DTPA PEG Biotin
DTPA PEG FITC
4A PEG DTPA
mPEG NTA
NTA PEG Biotin
NTA PEG FITC
4A PEG NTA
NTA PEG Biotin
NTA PEG Biotin
BSA PEG Conjugate
Polylysine PEG Conjugate
Polylysine PEG Conjugate
Dextran PEG Conjugate
Dextran PEG Conjugate
Chymotrypsin PEG Conjugate
Superoxide Dimutase PEG
